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Table 4 Summary of effects of mutations predicted by the automated methods

From: Associating mutations causing cystinuria with disease severity with the aim of providing precision medicine

  rBAT b(0+)AT
SIFT – Tolerated 23 11
SIFT – Damaging 70 48
PolyPhen2 (HumVar) – benign 12 14
PolyPhen2 (HumVar) – possibly damaging 15 16
PolyPhen2 (HumVar) – probably damaging 66 29
PolyPhen2 (HumDiv) – benign 8 15
PolyPhen2 (HumDiv) – possibly damaging 11 4
PolyPhen2 (HumDiv) – probably damaging 74 40
MutationAssessor – neutral 2 4
MutationAssessor – low 17 6
MutationAssessor – medium 40 29
MutationAssessor - high 34 20
FATHMM – Neutral 0 0
FATHMM – Damaging 93 59
Condel - Neutral 1 7
Condel – Damaging 92 52
CADD- Neutral 5 6
CADD - Deleterious 88 53