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Fig. 2 | BMC Genomics

Fig. 2

From: Short DNA sequence patterns accurately identify broadly active human enhancers

Fig. 2

DRMs are not major drivers of broad enhancer activity in humans. a ROC curves for SVM-based classification of broadly active enhancers vs. length-matched genomic background (red), GC-matched genomic background (blue), and context-specific enhancers (purple) using the frequency of the four DRMs as features. The area under each curve (AUC) is given in parentheses. Shaded areas are bounded by the maximum and minimum observed ROC. Precision-recall curves are given in Additional file 1: Figure S8. b The distribution of occurrences for each DRM observed over 1961 broadly active enhancers. Most enhancers do not contain each class of DRM. Box plots show median and 1st/3rd quartiles

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