Fig. 1

AcrC was identified through alignment with transcriptional regulators from acarbose biosynthetic gene clusters of streptomycetes. The protein alignment of AcrC from Actinoplanes sp. SE50/110, GarC1 and GarC2 from S. glaucescens as well as ScarC1 and ScarC2 from S. coelicoflavus is shown. The protein domains were determined with Pfam [62] and refer to the exact amino acid positions of AcrC. The alignment was performed with MUSCLE [21] in Geneious [63]