Residueb | Residues in the positionc | Conservation (%)d | Remarkse |
---|---|---|---|
I45 (TM1) | I(55), V, M, L | 96.7 | Hydrophobic |
F75 (TM2a) | F(79), Y | 98.8 | Part of the central constriction |
C82 (TM2a) | V(52), I, L | 93.0 | Hydrophobic |
V83 (TM2a) | V(39), I(33), L, M | 86.7 | Hydrophobic |
D88 (Ω-loop) | E(58), D | 80.7 | Acidic |
L89 (Ω-loop) | L(99) | 99.9 | Part of cytoplasmic slit (closed) |
T91 (Ω-loop) | T(98) | 97.9 | Part of cytoplasmic slit (closed) |
S92 (Ω-loop) | G(50), S, A | 79.1 | End of Ω-loop; small and weakly polar |
N121 (TM3) | N(99) | 99.4 | Hydrophilic, invariant |
A171 (TM4) | C(62), S, A, G | 99.9 | Close to S-loop; small and weakly polar |
N172 (TM4) | N(78) | 78.4 | Part of cytoplasmic slit (open) |
V175 (TM4) | V(81), I, M | 99.9 | Part of cytoplasmic slit (closed) |
V179 (TM4) | V(64), I, L, M | 86.2 | Hydrophobic |
K191 (TM5a) | K(83), R, E | 96.4 | Basic |
M195 (TM5a) | I(43), M, V, L | 88.2 | Hydrophobic |
V199 (TM5a) | I(39), L, V | 76.9 | Hydrophobic |
F202 (TM5) | F(78) | 78.5 | Part of central constriction ring |
G206 (S-loop) | G(74), S, T | 79.0 | Small and weakly polar |
H209 (S-loop) | H(99) | 98.7 | Part of central constriction ring |
N213 (TM5b) | N(76) | 76.5 | Hydrophilic |
N262 (TM6) | N(100) | 100.0 | Hydrophilic, invariant |