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Table 6 FNT channels with unique cytoplasmic slit in the open state

From: Anion-selective Formate/nitrite transporters: taxonomic distribution, phylogenetic analysis and subfamily-specific conservation pattern in prokaryotes

FNT subfamily UniProt IDa (Organism) Cytoplasmic slit residuesb CHI/CVV valuec
NirC-α A3WW31(Nitrobacter sp.)
A4BNG3 (Nitrococcus mobilis)
D5BVC1 (Nitrosococcus halophilus)
I4EJX4 (Nitrolancea hollandica)
Q82WJ4 (Nitrosomonas europaea)
YMANV CHI: +3.1
HSC F0JF84 (Desulfovibrio desulfuricans) LLVTL CHI: +14.9
NirC-γ S4D5T6, V7ZKG7 (Enterococcus faecalis)
S4EBH9, T2NT11 (Enterococcus faecium)
T0U7W5 (Enterococcus sp.)
T4JYM3 (Peptoclostridium difficile)
U5SBH7 (Carnobacterium inhibens)
V5XL10 (Enterococcus mundtii) and 41 more
LLGNV CVV: 497 Ǻ3
Unclassified I0JHL8 (Halobacillus halophilus)
K2GJH2 (Salimicrobium jeotgali)
L5N8D2 (Halobacillus sp.)
Q8ES73 (Oceanobacillus iheyensis)
YLFNI CVV: 620 Ǻ3
  1. aThe unique UniProt Accession ID is given
  2. bThe five residues that form cytoplasmic slit in the open state of the channel. They correspond to L79 from TM2a, L89 and F90 from Ω-loop and N172 and V175 from TM4 of the formate channel (PDB ID: 3KCU). Residues shown in bold will become part of the cytoplasmic slit in the open state when the Ω-loop undergoes conformational changes
  3. cCalculation of Cumulative Hydropathy Index (CHI) and Cumulative vdw Volume (CVV) are described in the text