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Fig. 6 | BMC Genomics

Fig. 6

From: PiiL: visualization of DNA methylation and gene expression data in gene pathways

Fig. 6

A subsection of the “TNF signaling pathway” leading into the apoptosis pathway, showing genes FADD, CASP10, CASP8, CASP7 and CASP3. FADD, CASP7 and CASP3 are not subject to DNAm changes when comparing IDH wildtype to mutants. CASP10 exhibits somewhat higher methylation levels, but remains stable at expression. By contrast, sites selected by Saguaro in CASP8 exhibit higher methylation levels in mutants, as well a correlated downregulation of expression. CASP3 and CASP7, which are downstream of the CASCADE from CASP8, are almost entirely silenced in expression

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