Fig. 1

Pan-genome and functional classification of genes of the Bifidobacteriaceae family. Panel a shows the pan-genome represented as variations of the sizes of the resulting gene pool upon sequential addition of the 67 Bifidobacteriaceae genomes. The x axis represents the number of included genomes, whereas the y axis represents the number of genes in the generated pan-genome. Panel b exhibits the number of core BaeCOGs associated with the predicted EggNOG classification. Panel c displays the percentages of TUGs associated with functional categories as classified through the EggNOG database between bifidobacterial and members of the Bifidobacteriaceae family that do not belong to the Bifidobacterium genus. COG families are identified by a one-letter abbreviation: A, RNA processing and modification; B, chromatin structure and dynamics; C, energy production and conversion; D, cell cycle control and mitosis; E, amino acid metabolism and transport; F, nucleotide metabolism and transport; G, carbohydrate metabolism and transport; H, coenzyme metabolism; I, lipid metabolism; J, translation; K, transcription; L, replication and repair; M, cell wall/membrane/envelope biogenesis; N, cell motility; O, post translational modification, protein turnover, and chaperone functions; P, inorganic ion transport and metabolism; Q, secondary structure; T, signal transduction; U, intracellular trafficking and secretion; Y, nuclear structure; V, defense mechanisms; Z, cytoskeleton; R, general functional prediction only; S, function unknown