Table 2 Genes significantly down-regulated in Escherichia coli O157:H7 EDL933 in samples with microbiota compared to those without microbiota
Locus (Z #) | Gene name | Mean of normalized counts | FCa | adj. p b | Function or product |
|---|---|---|---|---|---|
Nitrate metabolism and nitrite detoxification | |||||
 1107 | hcp | 270 | −2.5 | 3.2E-08 | Hybrid-cluster [4Fe-2S-2O] protein in anaerobic terminal reductases |
Amino acid transport and metabolism | |||||
 0037 | carA | 369 | −2.3 | 1.8E-07 | Carbamoyl phosphate synthetase small subunit, glutamine amidotransferase |
 1090 | artJ | 1305 | −4.0 | 8.4E-15 | Arginine transporter subunit; periplasmic-binding component of ABC superfamily |
 1093 | artI | 407 | −2.0 | 0.0002 | Arginine transporter subunit; periplasmic-binding component of ABC superfamily |
 3181 | hisG | 221 | −2.0 | 0.001 | ATP phosphoribosyltransferase |
 3569 | hisM | 208 | −2.0 | 0.0008 | Histidine/lysine/arginine/ornithine transporter subunit; membrane component of ABC superfamily |
 4135 | argA | 737 | −2.5 | 2.7E-07 | Fused acetylglutamate kinase homolog (inactive); amino acid N-acetyltransferase |
 4534 | argG | 972 | −3.0 | 9.9E-12 | Argininosuccinate synthetase |
 5285 | ilvC | 773 | −2.0 | 2.1E-05 | Ketol-acid reductoisomerase. NAD(P)-binding |
 5515 | argE | 448 | −2.5 | 2.8E-09 | Acetylornithine deacetylase |
 5516 | argC | 1480 | −3.7 | 1.4E-16 | N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding |
 5517 | argB | 533 | −2.8 | 1.1E-09 | Acetylglutamate kinase |
 5518 | argH | 1496 | −2.5 | 7.2E-06 | Argininosuccinate lyase |
 5719 | adiA | 539 | −2.1 | 0.001 | Biodegradative arginine decarboxylase |
 5866 | argI | 404 | −2.5 | 0.0006 | Ornithine carbamoyltransferase 1 |
bacterial pathogenicity | |||||
 3200 | peR | 739 | −2.0 | 6.9E-05 | Perosamine synthetase Per |