Skip to main content

Table 2 Candidate protective nsSNPs

From: Identification of candidate protective variants for common diseases and evaluation of their protective potential

  Disease Gene rsID Chr Position Anc Der ORb SNPs in high LD set Mean iHS GWAS
1 Multiple sclerosis IL7R rs6897932 5 35,874,575 C T 1.12 6 −1.462 [34]
2 Glaucoma (primary open-angle) COL11A1 rs3753841 1 103,379,918 G A 1.20 22 −1.270 [35]
3 Type 2 diabetes SLC30A8 rs13266634 8 118,184,783 C T 1.16 5 −1.218 [36]a
4 Psoriasis TYK2 rs12720356 19 10,469,975 A C 1.40 1 −1.197 [37]
5 Acute lymphoblastic leukemia (childhood) KCNE4 rs12621643 2 223,917,983 T G 1.48 3 −1.167 [38]
6 Ulcerative colitis IL17REL rs5771069 22 50,435,480 G A 1.11 10 −1.121 [39]
7 Esophageal cancer and gastric cancer PLCE1 rs3765524 10 96,058,298 T C 1.35 23 −0.897 [40]
8 IgA nephropathy TNFSF13 rs3803800 17 7,462,969 A G 1.21 23 −0.819 [41]
9 Systemic lupus erythematosus WDFY4 rs7097397 10 50,025,396 G A 1.30 18 −0.767 [42]
10 Esophageal cancer PLCE1 rs2274223 10 96,066,341 G A 1.34 38 −0.740 [43]
11 AMD CFB rs641153 6 31,914,180 G A 2.44 13 −0.723 -
12 Inflammatory bowel disease CD6 rs11230563 11 60,776,209 C T 1.09 21 −0.705 [44]
13 Behcet’s disease KLRC4 rs2617170 12 10,560,957 T C 1.28 46 −0.657 [45]
14 Coronary heart disease ZC3HC1 rs11556924 7 129,663,496 C T 1.09 6 −0.649 [46]
15 Type 1 diabetes TYK2 rs2304256 19 10,475,652 C A 1.16 7 −0.627 [47]
16 Obesity GIPR rs1800437 19 46,181,392 G C 1.1 10 −0.606 [48]
17 AMD C2 rs9332739 6 31,903,804 G C 1.82 9 −0.551 -
18 Type 2 diabetes PPARG rs1801282 3 12,393,125 C G 1.14 11 −0.537 [49]
19 Inflammatory bowel disease TUBD1 rs1292053 17 57,963,537 G A 1.08 41 −0.498 [44]
20 Migraine MMP17 rs6598163 12 132,325,239 G A 1.15 22 −0.493 [50]
21 Glaucoma (exfoliation) LOXL1 rs3825942 15 74,219,582 G A 20.1 26 −0.453 [51]
22 Inflammatory bowel disease IL23R rs11209026 1 67,705,958 G A 2.01 2 −0.410 [52]
23 Multiple sclerosis MPV17L2 rs874628 19 18,304,700 A G 1.11 8 −0.292 [53]
24 Rheumatoid arthritis RTKN2 rs3125734 10 63,958,112 T C 1.20 12 −0.263 [54]
25 Interstitial lung disease LRRC34 rs6793295 3 169,518,455 C T 1.30 19 −0.228 [55]
26 Obesity SH2B1 rs7498665 16 28,883,241 G A 1.07 27 −0.210 [48]
27 Breast cancer ANKLE1 rs8100241 19 17,392,894 G A 1.14 11 −0.185 [56]
28 Systemic lupus erythematosus BANK1 rs10516487 4 102,751,076 G A 1.38 8 −0.184 [57]
29 Ovarian cancer ANKLE1 rs2363956 19 17,394,124 T G 1.10 13 −0.153 [58]
30 Rheumatoid arthritis NFKBIE rs2233434 6 44,232,920 G A 1.20 32 −0.114 [59]
- Hypertension LPL rs328 8 19,819,724 C G - 28 −0.031 -
31 Type 2 diabetes WFS1 rs1801214 4 6,303,022 T C 1.13 8 0.314 [60]
32 Type 2 diabetes THADA rs7578597 2 43,732,823 T C 1.15 49 0.379 [61]
33 Psoriasis IL13 rs20541 5 131,995,964 G A 1.27 8 0.872 [62]
34 Prostate cancer MLPH rs2292884 2 238,443,226 G A 1.14 40 0.883 [63]
  1. adenotes the nsSNP has been detected by more than one GWAS in the catalog, we only report the first chronologically
  2. bOR for ancestral allele