Table 4 KEGG biochemical mapping of the genes harboring SNPs with allelic imbalances in fish families showing contrasting growth and muscle phenotypes

KEGG categories

No. of sequences (%)

No. of KOs

No. of sequences (%)

No. of KOs

No. of sequences (%)

No. of KOs

No. of sequences (%)

No. of KOs

No. of sequences (%)

No. of KOs

No. of sequences (%)

No. of KOs

Metabolism

275

182

133

99

130

96

102

77

125

92

142

105

Carbohydrate Metabolism

77 (28.00)

43

42(31.58)

28

39 (30.00)

27

26 (25.49)

19

39 (31.20)

25

47 (33.10)

28

  Glycollysis / Gluconeogenesis

39

18

19

10

19

14

13

7

21

11

20

13

  Citrate cycle (TCA cycle)

19

14

8

8

9

7

7

6

10

9

9

7

  Pyruvate metabolism

16

10

6

4

7

7

5

4

10

8

6

5

  Pentose phosphate pathway

13

5

8

5

7

5

7

3

3

2

3

3

Energy Metabolism

88 (32.00)

57

42 (31.58)

32

45 (34.62)

29

37 (36.27)

26

30 (24.00)

21

41 (28.87)

32

  Oxidative phosphorylation

52

37

20

17

28

18

18

15

13

11

19

16

Amino Acid Metabolism

56 (20.36)

41

26 (19.55)

21

24 (18.46)

20

2 (20.59)

16

28 (22.40)

22

32 (22.54)

26

Lipid Metabolism

27 (9.82)

22

14 (10.53)

11

11 (8.46)

11

7 (6.86)

6

16 (12.80)

14

13 (9.15)

11

  Fatty acid degradation

15

13

8

6

9

9

4

3

11

10

8

7

Metabolism Cofactors and Vitamins

14 (5.09)

11

4 (3.01)

4

6 (4.62)

4

5 (4.90)

5

5 (4.00)

5

4 (2.82)

4

Nucleotide Metabolism

13 (4.73)

8

5 (3.76)

3

5 (3.85)

5

6 (5.88)

5

7 (5.60)

5

5 (3.52)

4

Genetic Informatio Processing

176

112

69

50

79

59

50

40

83

59

74

55

Translation

105 (59.66)

69

36 (52.19)

31

48 (60.76)

39

30 (60.00)

27

45 (54.22)

35

47 (63.51)

40

  Ribosome

68

48

25

23

32

26

21

19

33

27

32

28

  RNA transport

22

12

9

6

11

9

7

6

8

4

7

6

Folding. Sorting and Degradation

62 (35.23)

38

28 (40.58)

17

24 (30.38)

16

19 (38.00)

12

30 (36.14)

19

23 (31.08)

13

  Protein processing in endoplasmic reticulum

23

14

11

7

7

4

7

5

14

9

7

4

  RNA Degradation

16

5

11

4

10

5

8

4

9

3

11

5

  Proteasome

12

11

4

4

5

5

1

1

4

4

4

3

  Ubiquitin mediated proteolysi

9

7

2

2

2

2

1

1

3

3

1

1

Transcription

9 (5.11)

5

5 (7.25)

2

7 (8.86)

4

1 (2.00)

1

8 (9.64)

5

4 (5.41)

2

  Spliceosome

9

5

5

2

7

4

1

1

8

5

4

2

Environmental Information Processing

166

99

70

45

88

61

62

45

76

55

87

58

Signal Transduction

147 (88.55)

87

62 (88.57)

39

79 (89.77)

53

56 (90.32)

41

69 (90.79)

50

74 (85.06)

50

  P13K-Akt signaling pathway

35

21

12

8

13

10

12

8

13

10

24

16

  Calcium signaling pathway

36

18

16

9

13

8

14

10

16

12

16

11

  MAPK signaling pathway

26

18

10

6

17

12

7

6

12

9

10

8

  cGMP-PKG signaling pathway

26

16

10

7

8

8

7

6

10

8

12

10

  AMPK signaling pathway

21

12

10

5

14

8

9

3

10

6

12

7

  cAMP signaling pathway

18

12

6

5

4

4

7

6

8

7

7

6

  HIF-1signaling pathway

11

9

4

2

7

4

3

3

9

6

8

4

  Hippo signaling pathway

13

7

2

2

7

5

6

6

5

5

5

4

  FoxO signaling pathway

7

6

3

3

2

2

3

3

1

1

3

3

  mTOR signaling pathway

5

5

1

1

2

2

0

0

1

1

3

3

Signaling Molecules and Interaction

19 (11.45)

12

8 (11.43)

6

9 (10.23)

8

6 (9.68)

4

7 (9.21)

5

13 (14.94)

8

  ECM-receptor interaction

17

10

7

5

7

6

6

4

7

5

13

8

  Cell adhesion molecules

3

2

1

1

2

2

0

0

0

0

2

1

Cellular Processes

152

85

68

41

70

42

54

4

64

44

83

56

Cellular community

54 (35.53)

27

27 (39.71)

13

29 (41.43)

15

26 (48.15)

16

27 (42.19)

16

36 (43.37)

21

  Focal adhesion

35

21

13

10

17

11

14

11

15

11

23

17

  Tight junction

19

10

18

6

17

6

15

8

16

7

10

6

  Gap juction

8

2

1

1

1

1

2

2

2

2

7

2

  Adherens junction

5

3

4

3

5

3

3

3

5

3

3

3

Transport and Catabolism

42 (27.63)

24

17 (25.00)

11

20 (28.57)

14

8 (17.81)

8

16 (25.00)

11

18 (21.69)

11

Cell Growth and Death

36 (23.68)

22

16 (23.53)

11

1217.14

8

13 (24.07)

12

14 (21.88)

13

19 (22.89)

16

  Apoptosis

19

13

13

7

5

4

6

6

7

7

11

9

  p53 signaling pathway

7

5

6

4

3

1

1

1

3

3

4

4

Cell Motility

20 (13.16)

12

8 (11.76)

6

9 (12.86)

5

7 (12.96)

6

7 (10.94)

4

10 (12.05)

8

  Regulation of actin cytoskeleton

20

12

8

6

9

5

7

6

7

4

10

8

Organismal Systems

274

154

108

66

124

84

109

81

122

82

129

89

Endocrine System

105 (38.32)

53

44 (40.74)

25

49 (39.52)

32

36 (33.03)

24

53 (43.44)

3

56 (43.41)

33

  Glucagon signaling pathway

36

12

19

8

14

9

12

7

22

11

23

10

  Insulin signaling pathway

32

12

14

7

11

6

7

4

12

6

22

10

  Thyroid hormone signaling pathway

11

7

4

4

6

5

3

3

4

4

6

6

  Thyroid hormone synthesis

6

4

3

2

1

1

3

3

2

2

1

1

Circulatory System

49 (17.88)

30

18 (16.67)

12

22 (17.74)

15

19 (17.43)

16

16 (13.11)

13

15 (11.63)

12

Immune System

44 (16.06)

28

16 (17.81)

10

21 (16.94)

14

22 (20.18)

17

24 (19.67)

16

23 (17.83)

17

Digestive System

32 (11.68)

16

13 (12.04)

9

9 (7.26)

7

18 (16.54)

11

13 (10.66)

9

20 (15.50)

14

  Protein digestion and absorption

12

5

6

4

7

5

8

5

5

3

8

4

  Mineral absorption

4

2

1

1

1

1

2

2

1

1

2

2

Nervous System

27 (9.85)

17

7 (6.48)

5

12 (9.68)

9

11 (10.09)

10

10 (8.20)

9

9 (6.98)

8

Aging

17 (6.20)

10

10 (9.26)

5

11 (8.87)

7

3 (2.75)

3

6 (4.92)

2

6 (4.65)

5

Total

1043

632

448

301

491

342

377

285

470

332

515

363