Fig. 1
From: Genome-wide gene expression analysis in the placenta from fetus with trisomy 21
Comparison of differentially expressed genes in adult brain, fetal brain, and fetal placenta of T21. The up-regulated genes in the adult brains, fetal brains, and fetal placentas with T21 were 1027, 156, and 77, respectively (a). Of the up-regulated genes, 12 (APP, C21orf33, C2CD2, CSTB, HSPA13, LTN1, MORC3, MRPL39, NRIP1, PTTG1IP, TRAPPC10, USP16) were commonly up-regulated in all tissues, regardless of tissue types and developmental stages (a). The down-regulated genes in the adult brains, fetal brains, and fetal placentas with T21 were 179, 373, and 33, respectively (b). None of the down-regulated genes were commonly down-regulated across the tissue types and developmental stages. Two genes (CDKAL1 and GJC1) were down-regulated in both fetal brains and fetal placentas (b)