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Table 5 Pathway analysis of candidate genes

From: Genome-wide gene expression analysis in the placenta from fetus with trisomy 21

Pathway name of KEGG Gene symbol rawP adjP
Up regulation in T21 Down regulation in T21
Whole genome
 Focal adhesion FLT1, MET, MYLK3 COL4A5, HGF, LAMC3 1.32e-05 3.01e-05
 Alzheimer’s disease APP,ATP5J,ATP5O, BACE2, NDUFV3 - 7.23e-05 9.15e-05
 Parkinson’s disease ATP5J, ATP5O, NDUFV3, UBE2G2 - 4.00e-04 3.24e-03
 Pathways in cancer FZD5, MET COL4A5, HGF, LAMC3 1.51e-03 7.21e-03
 Cytokine-cytokine receptor interaction FLT1, LEP, MET HGF 4.79e-03 1.44e-02
 Metabolic pathways AGPAT3, ATP5J, ATP5O, GART, NDUFV3, SYNJ1 ANPEP 2.59e-02 3.45e-02
Chromosomes other than HSA21
 Focal adhesion FLT1, MET, MYLK3 COL4A5, HGF, LAMC3 5.53e-07 9.95e-06
 Pathways in cancer FZD5, MET COL4A5, HGF, LAMC3 1.00e-04 9.00e-04
 Cytokine-cytokine receptor interaction FLT1, LEP, MET HGF 7.00e-04 4.20e-03
  1. HSA21 human chromosome 21, T21 trisomy 21, rawP: p value from hypergeometric test, adjP: p value adjusted by the multiple test adjustment