MicroRNA expression in bone marrow-derived human multipotent Stromal cells

BMC Genomics

Table 1 Significant Differences in miRNA expression between Passages [P3, P5, P7]

#	miRNA Name	Sequence	P5/P3	P5/P3	P7/P3	P7/P3
			Adjusted	Fold	Adjusted	Fold
			p-value	Change	p-value	Change
1	hsa-miR-196b-5p	CCCAACAACAGGAAACTAC	0.0294	−1.05	0.0231	−1.05
2	hsa-miR-16-5p	CGCCAATATTTACGTGCTG	0.0464	−1.33	0.0334	−1.39
3	hsa-miR-1202	CTCCCCCACTGC	0.0294	1.39	0.0334	1.32
4	hsa-let-7 g-5p	AACTGTACAAACTACTACCT	0.0049	−1.19	0.0161	−1.15
5	hsa-miR-572	TGGGCCACCGCCG	0.0385	1.24	0.0335	1.26
6	hsa-miR-92a-3p	ACAGGCCGGGACAAGT	0.0334	−1.21	0.0385	−1.19
7	hsa-miR-638	AGGCCGCCACCCG	0.0464	1.28	0.0232	1.45
7	hsa-miR-638	AGGCCGCCACCCGC	0.0385	1.38	0.0310	1.49
8	hsa-miR-1915-3p	CCCGCCGCGTC	NS	NS	0.0385	1.32
9	hsa-miR-17-5p	CTACCTGCACTGTAAGC	NS	NS	0.0335	−1.22
10	hsa-miR-29b-1-5p	TCTAAACCACCATATGAAACCAG	NS	NS	0.0380	−1.13
11	hsa-miR-15b-5p	TGTAAACCATGATGTGCTG	NS	NS	0.0335	−1.42

NS Not Significant
A repeated measures ANOVA was performed on the 6 MSC donors that grew to passage 7. Positive fold change indicates upregulation in MSC expression at passage 7, while negative fold change indicates downregulation in MSC expression at passage 7

ISSN: 1471-2164