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Fig. 3 | BMC Genomics

Fig. 3

From: Equine skeletal muscle adaptations to exercise and training: evidence of differential regulation of autophagosomal and mitochondrial components

Fig. 3

Cellular functions of the training response. Bar charts showing over-representation of functional categories (described by KEGG and REACTOME pathways and Gene Ontology: Biological Process, Molecular Function and Cellular Component) for the list of genes (n = 3405) that showed statistically significant differential expression, of at least +/− 1.25-fold, between the muscle tissue (gluteus medius) from the untrained rest (UR) and the trained rest (TR) Thoroughbred cohorts. Bars represent the most significant functional modules (up to 20) for each of the five annotation schemas. Bar height represents statistical significance (−log 10 transformed Benjamini-Hochberg (B-H) Corrected P-value) of the over-representation, based on the EASE-score (conservative Fisher Exact t-test). Bar color represents the mean differential expression (log2(TR/UR) for the genes in this module (see color key). Category name, ID and size (number category genes in gene list/category size) are given above each bar. For example it can be seen that the most significant Gene Ontology:Biological Process is ‘Integration of energy metabolism’ and that this functional categories is up-regulated on average (orange color) and that 95 out of the 219 genes assigned to this category are differentially expressed between TR and UR cohorts. Full results are provided in Additional file 2: Table S5

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