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Table 2 The top twenty hub (based on node degree, D) and bottleneck (based on node betweenness, B) genes in the Exercise Response network in the Untrained Rest (UR) and Untrained Exercise (UE) states

From: Equine skeletal muscle adaptations to exercise and training: evidence of differential regulation of autophagosomal and mitochondrial components

Untrained Rest Untrained Exercise Unique to Untrained Exercise
Hubs D Bottlenecks B Hubs D Bottlenecks B Hubs D Bottlenecks B
GABARAPL1 33 GABARAPL1 20,436 GABARAPL1 25 GABARAPL1 6905 FN1 15 FN1 888
TCTN3 21 ESR1 18,589 FN1 19 FN1 6881 LIMA1 11 LIMA1 826
NDUFA6 19 TRIM54 13,553 LIMA1 16 DNAJB1 6327 APOA1 5 FLNB 756
SIRT4 18 GNB4 13,514 NDUFA6 16 CDC37 5983 TRIM54 5 APOA1 394
FN1 16 CDK18 13,394 CDC37 14 LIMA1 2799 TMEM216 5 CAV1 346
GRB2 16 CDC37 10,875 MYO18A 13 TRIM54 2444 ESR1 5 ESR1 246
NDUFA2 15 FLNB 10,484 TMEM216 11 HSPH1 2338 BAG3 4 TMEM216 210
FASTKD3 15 AHNAK 10,125 MYO19 10 NR4A1 2210 TCTN3 4 TNS3 207
ESR1 10 MYO18A 9786 SPTBN1 9 FLNB 2123 TUBB3 4 RAB1A 158
TRIM54 9 TCTN3 9292 TRIM54 8 SMAD3 2094 FLNB 4 TUBB3 156
NCK1 9 GRB2 8676 ESR1 8 APOA1 1759 PIK3R1 4 AHNAK 120
MEOX2 8 FN1 7852 TCTN3 7 CAV1 1707 SMAD3 3 KIT 107
ATP5F1 8 HOMER3 7598 FLNB 7 RARG 1691 KIT 3 SCRIB 106
CDC37 8 ZBTB4 7364 MEOX2 6 TMEM216 1659 TNS3 3 FAS 54
TMEM216 8 CCDC57 7154 ATP5F1 6 ESR1 1603 CAV1 3 DMWD 54
ACAD9 7 CEP57L1 6650 SYNPO 6 SPTBN1 1484 CETN3 3 ITPR3 54
PCM1 7 PCM1 6593 SMAD3 5 RAB1A 1322 RAB1A 3 FASN 54
HDAC1 6 SYNPO 6545 TUBB3 5 PRKAR1B 1300 NR4A1 3 ANXA1 54
NDUFS2 6 PPP1R12B 6084 APOA1 5 PFKL 1162 HSF2 3 ELMSAN1 54
TTN 6 SIRT4 5093 PLEC 5 MYO19 1095 FASN 3 STOM 54
  1. The top twenty hub and bottleneck genes are also provided for the sub-network that was unique to the Exercise Response (i.e. constructed from genes differentially expressed in response to exercise but not training)