Equine skeletal muscle adaptations to exercise and training: evidence of differential regulation of autophagosomal and mitochondrial components

Table 2 The top twenty hub (based on node degree, D) and bottleneck (based on node betweenness, B) genes in the Exercise Response network in the Untrained Rest (UR) and Untrained Exercise (UE) states

Untrained Rest				Untrained Exercise				Unique to Untrained Exercise
Hubs	D	Bottlenecks	B	Hubs	D	Bottlenecks	B	Hubs	D	Bottlenecks	B
GABARAPL1	33	GABARAPL1	20,436	GABARAPL1	25	GABARAPL1	6905	FN1	15	FN1	888
TCTN3	21	ESR1	18,589	FN1	19	FN1	6881	LIMA1	11	LIMA1	826
NDUFA6	19	TRIM54	13,553	LIMA1	16	DNAJB1	6327	APOA1	5	FLNB	756
SIRT4	18	GNB4	13,514	NDUFA6	16	CDC37	5983	TRIM54	5	APOA1	394
FN1	16	CDK18	13,394	CDC37	14	LIMA1	2799	TMEM216	5	CAV1	346
GRB2	16	CDC37	10,875	MYO18A	13	TRIM54	2444	ESR1	5	ESR1	246
NDUFA2	15	FLNB	10,484	TMEM216	11	HSPH1	2338	BAG3	4	TMEM216	210
FASTKD3	15	AHNAK	10,125	MYO19	10	NR4A1	2210	TCTN3	4	TNS3	207
ESR1	10	MYO18A	9786	SPTBN1	9	FLNB	2123	TUBB3	4	RAB1A	158
TRIM54	9	TCTN3	9292	TRIM54	8	SMAD3	2094	FLNB	4	TUBB3	156
NCK1	9	GRB2	8676	ESR1	8	APOA1	1759	PIK3R1	4	AHNAK	120
MEOX2	8	FN1	7852	TCTN3	7	CAV1	1707	SMAD3	3	KIT	107
ATP5F1	8	HOMER3	7598	FLNB	7	RARG	1691	KIT	3	SCRIB	106
CDC37	8	ZBTB4	7364	MEOX2	6	TMEM216	1659	TNS3	3	FAS	54
TMEM216	8	CCDC57	7154	ATP5F1	6	ESR1	1603	CAV1	3	DMWD	54
ACAD9	7	CEP57L1	6650	SYNPO	6	SPTBN1	1484	CETN3	3	ITPR3	54
PCM1	7	PCM1	6593	SMAD3	5	RAB1A	1322	RAB1A	3	FASN	54
HDAC1	6	SYNPO	6545	TUBB3	5	PRKAR1B	1300	NR4A1	3	ANXA1	54
NDUFS2	6	PPP1R12B	6084	APOA1	5	PFKL	1162	HSF2	3	ELMSAN1	54
TTN	6	SIRT4	5093	PLEC	5	MYO19	1095	FASN	3	STOM	54

The top twenty hub and bottleneck genes are also provided for the sub-network that was unique to the Exercise Response (i.e. constructed from genes differentially expressed in response to exercise but not training)

ISSN: 1471-2164