Table 3 The top twenty hub (based on node degree, D) and bottleneck (based on node betweenness, B) genes in the Exercise Response network in the Untrained Rest (UR) and Trained Exercise (TR) states
Untrained Rest | Trained Rest | Unique to Trained Rest | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Hubs | D | Bottlenecks | B | Hubs | D | Bottlenecks | B | Hubs | D | Bottlenecks | B |
NDUFA6 | 20 | GABARAPL1 | 819 | NDUFA6 | 19 | GABARAPL1 | 2137 | KDR | 3 | MAPK10 | 6 |
GABARAPL1 | 19 | NDUFA4 | 459 | GABARAPL1 | 15 | ATP5C1 | 1631 | TUBA1A | 3 | ARRB1 | 6 |
NDUFA2 | 15 | NDUFA6 | 432 | NDUFA2 | 14 | SPTBN1 | 1135 | NCOA4 | 2 | KDR | 5 |
ATP5F1 | 8 | NDUFA2 | 320 | ATP5F1 | 8 | NDUFB3 | 1067 | NIN | 2 | JUN | 4 |
GRB2 | 7 | GRB2 | 177 | SPTBN1 | 5 | PRDX2 | 935 | JUN | 2 | APP | 4 |
CDC37 | 6 | MYO18A | 158 | ACAD9 | 5 | NDUFA2 | 933 | MAPK10 | 2 | NCOA4 | 3 |
ACAD9 | 6 | ATP5F1 | 125 | MYO19 | 5 | SYNPO | 842 | ARRB1 | 2 | TUBA1A | 3 |
NCK1 | 6 | NDUFV3 | 98 | MYO18A | 5 | A2M | 814 | APP | 2 | NIN | 1 |
TUBA1A | 5 | ATP5A1 | 88 | MAPK6 | 4 | NDUFA6 | 777 | RIPK4 | 2 | RIPK4 | 1 |
MYO18A | 5 | ASB16 | 85 | ARAF | 4 | MYO18A | 608 | TNKS2 | 1 | TNKS2 | 0 |
CACNA1A | 4 | ATP5B | 82 | LUZP1 | 4 | ARAF | 565 | IPO4 | 1 | IPO4 | 0 |
ATP5B | 4 | NCK1 | 82 | KDR | 4 | MYO19 | 549 | EGLN3 | 1 | EGLN3 | 0 |
HSF2BP | 4 | CAPZB | 78 | PRDX2 | 4 | APP | 509 | LUZP1 | 1 | LUZP1 | 0 |
ATP5C1 | 4 | ACAD9 | 76 | PDLIM7 | 4 | ACAD9 | 401 | C1QB | 1 | C1QB | 0 |
MAPK6 | 3 | ATP5J2 | 76 | SYNPO | 4 | ATP5F1 | 395 | C1QA | 1 | C1QA | 0 |
EGLN3 | 3 | ATP5C1 | 72 | ATP5C1 | 4 | TPRN | 323 | SPRY1 | 1 | SPRY1 | 0 |
HDAC1 | 3 | NDUFB3 | 64 | HDAC1 | 3 | PDLIM7 | 320 | FGF2 | 1 | FGF2 | 0 |
CAPZB | 3 | PHYHIP | 50 | SPRY1 | 3 | ACADM | 320 | FGFBP1 | 1 | FGFBP1 | 0 |
KDR | 3 | DLD | 50 | NDUFS2 | 3 | ARRB1 | 246 | CACNA1A | 1 | CACNA1A | 0 |
NDUFA4 | 3 | PRDX2 | 50 | CDC37 | 3 | MYO1B | 246 | DYNLL1 | 1 | DYNLL1 | 0 |