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Table 3 The top twenty hub (based on node degree, D) and bottleneck (based on node betweenness, B) genes in the Exercise Response network in the Untrained Rest (UR) and Trained Exercise (TR) states

From: Equine skeletal muscle adaptations to exercise and training: evidence of differential regulation of autophagosomal and mitochondrial components

Untrained Rest Trained Rest Unique to Trained Rest
Hubs D Bottlenecks B Hubs D Bottlenecks B Hubs D Bottlenecks B
NDUFA6 20 GABARAPL1 819 NDUFA6 19 GABARAPL1 2137 KDR 3 MAPK10 6
GABARAPL1 19 NDUFA4 459 GABARAPL1 15 ATP5C1 1631 TUBA1A 3 ARRB1 6
NDUFA2 15 NDUFA6 432 NDUFA2 14 SPTBN1 1135 NCOA4 2 KDR 5
ATP5F1 8 NDUFA2 320 ATP5F1 8 NDUFB3 1067 NIN 2 JUN 4
GRB2 7 GRB2 177 SPTBN1 5 PRDX2 935 JUN 2 APP 4
CDC37 6 MYO18A 158 ACAD9 5 NDUFA2 933 MAPK10 2 NCOA4 3
ACAD9 6 ATP5F1 125 MYO19 5 SYNPO 842 ARRB1 2 TUBA1A 3
NCK1 6 NDUFV3 98 MYO18A 5 A2M 814 APP 2 NIN 1
TUBA1A 5 ATP5A1 88 MAPK6 4 NDUFA6 777 RIPK4 2 RIPK4 1
MYO18A 5 ASB16 85 ARAF 4 MYO18A 608 TNKS2 1 TNKS2 0
CACNA1A 4 ATP5B 82 LUZP1 4 ARAF 565 IPO4 1 IPO4 0
ATP5B 4 NCK1 82 KDR 4 MYO19 549 EGLN3 1 EGLN3 0
HSF2BP 4 CAPZB 78 PRDX2 4 APP 509 LUZP1 1 LUZP1 0
ATP5C1 4 ACAD9 76 PDLIM7 4 ACAD9 401 C1QB 1 C1QB 0
MAPK6 3 ATP5J2 76 SYNPO 4 ATP5F1 395 C1QA 1 C1QA 0
EGLN3 3 ATP5C1 72 ATP5C1 4 TPRN 323 SPRY1 1 SPRY1 0
HDAC1 3 NDUFB3 64 HDAC1 3 PDLIM7 320 FGF2 1 FGF2 0
CAPZB 3 PHYHIP 50 SPRY1 3 ACADM 320 FGFBP1 1 FGFBP1 0
KDR 3 DLD 50 NDUFS2 3 ARRB1 246 CACNA1A 1 CACNA1A 0
NDUFA4 3 PRDX2 50 CDC37 3 MYO1B 246 DYNLL1 1 DYNLL1 0
  1. The top twenty hub and bottleneck genes are also provided for the sub-network that was unique to the Training Response (i.e. constructed from genes differentially expressed in response to training but not exercise)