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Fig. 1 | BMC Genomics

Fig. 1

From: Validation of β-lactam minimum inhibitory concentration predictions for pneumococcal isolates with newly encountered penicillin binding protein (PBP) sequences

Fig. 1

Comparison of the predicted β-Lactam MICs with phenotypic MICs specifically for “new” PBP types using the “leave-one-type-out” cross validation of Dataset1. All isolates of a PBP type were selected as the testing data and the remaining isolates were used as the training data. The MM (red) and RF (green) models were parametrized by the training data and then used to predict the MIC of the testing isolates, which represent a PBP type that was not included in the training data. The procedure was applied to each PBP type in turn, resulting in predicted MICs for each isolate in Dataset1, which were compared with the phenotypic MICs. a Percent Essential Agreement (MICs agree within ±1 2-fold dilution) between the predicted and phenotypic MICs. b Percent Category Agreement (interpretive results agree) between the predicted and phenotypic MICs. c Rate of major discrepancy (phenotypically sensitive isolate predicted as resistant). The number of phenotypically sensitive isolates that was used to calculate this rate is shown above the corresponding antibiotic. d Rate of very major discrepancy (phenotypically resistant isolate predicted as sensitive). The number of phenotypically resistant isolates that was used to calculate this rate is shown above the corresponding antibiotic. Error bars are 95% confidence intervals. PEN: penicillin; AMO: amoxicillin; MER: meropenem; TAX: cefotaxime; CFT: ceftriaxone; CFX: cefuroxime

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