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Fig. 4 | BMC Genomics

Fig. 4

From: Validation of β-lactam minimum inhibitory concentration predictions for pneumococcal isolates with newly encountered penicillin binding protein (PBP) sequences

Fig. 4

Comparison between the predicted β-Lactam MICs and phenotypic MICs for new PBP type in Dataset2. All isolates of Dataset1 were used to train the MM (red) and RF (green) models. The trained models were used to predict MICs of Dataset2 isolates that carried a PBP type not seen in Dataset1 (new PBP type). The resulting predicted MICs were compared with the phenotypic MICs of these Dataset2 isolates. a Percent Essential Agreement (MICs agree within ±1 2-fold dilution) between the predicted and phenotypic MICs. b Percent Category Agreement (interpretive results agree) between the predicted and phenotypic MICs. c Rate of major discrepancy (phenotypically sensitive isolate predicted as resistant). The number of phenotypically sensitive isolates that was used to calculate this rate is shown above the corresponding antibiotic. d Rate of very major discrepancy (phenotypically resistant isolate predicted as sensitive). The number of phenotypically resistant isolates that was used to calculate this rate is shown above the corresponding antibiotic. Error bars are 95% confidence intervals. PEN: penicillin; AMO: amoxicillin; MER: meropenem; TAX: cefotaxime; CFT: ceftriaxone; CFX: cefuroxime

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