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Table 5 Association between survival patterns predicted by the 19-miRNA prognostic classifier with clinico-pathologic characteristics or molecular subtypes in the TCGA cohort

From: Identification of common oncogenic and early developmental pathways in the ovarian carcinomas controlling by distinct prognostically significant microRNA subsets

Characteristic

Subcategory

Low risk

Intermediate risk

High risk

Weighted Kappa

(n =231 )

(n =215 )

(n =28)

Number

%

Number

%

Number

%

Correlation coefficient

P-value&

Age at initial pathologic diagnosis

age < 50

36

19%

53

20%

4

17%

0.02

0.55

50 <= age <=70

110

57%

143

55%

8

35%

  

age > 70

42

22%

58

22%

9

39%

  

*others/no information

4

2%

5

2%

2

9%

  

Stage

Stage I-II

22

11%

13

5%

0

0%

-0.06

0.026

Stage III

145

76%

203

78%

18

78%

  

Stage IV

25

13%

42

16%

5

22%

  

*others/no information

0

0%

1

0%

0

0%

  

Grade

Grade 1

30

16%

28

11%

3

13%

-0.03

0.17

Grade 2

157

82%

228

88%

18

78%

  

Grade 3

1

1%

0

0%

0

0%

  

*others/no information

4

2%

3

1%

2

9%

  

Tumor residual disease

No_Macroscopic_disease

52

27%

43

17%

0

0%

0.15

5.58E-4

1-20 mm

83

43%

144

56%

11

48%

  

>20_mm

27

14%

42

16%

7

30%

  

*others/no information

30

16%

30

12%

5

22%

  

Primary therapy outcome success

Complete response

130

68%

133

51%

5

22%

0.15

1.12E-3

Partial response/stable disease

23

12%

49

19%

7

30%

  

Progressive disease

11

6%

23

9%

1

4%

  

*others/no information

28

15%

54

21%

10

43%

  

^TCGA samples by molecular subtypes

Proliferative

61

32%

60

23%

3

13%

0.23

4.23E-8

Immunoreactive/Differentiated

102

53%

118

46%

6

26%

  

Mesenchymal

16

8%

71

27%

13

57%

  

*others/no information

13

7%

10

4%

1

4%

  

^TCGA samples by miRNA clustering

C1

54

28%

59

23%

0

0%

-0.07

0.034

C2

12

6%

89

34%

20

87%

  

C3

113

59%

101

39%

2

9%

  

*others/no information

13

7%

10

4%

1

4%

  

let-7b miRNA Classifier

Low Risk

119

62%

40

15%

0

0%

0.43

<1E-16

Intermediate Risk

72

38%

196

76%

9

39%

  

High Risk

1

1%

23

9%

14

61%

  
  1. The measure of agreement was calculated using weighted kappa correlation coefficient, and the significance of the agreement was estimated by kappa2* function in R package irr
  2. Note: *These subcategories are not included in the calculation of the Kappa correlation coefficient
  3. ^Sample groupings were provided by the authors of the TCGA study [14]
  4. &Significant associations are highlighted in boldface
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BMC Genomics

ISSN: 1471-2164

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