Table 6 Common significant signaling pathways using DIANA-miRPath analysis of miRNAs selected by DDSS, SWVg and K-means methods
KEGG pathway | 19 miRNAs | 21 miRNAs associated with let-7b [8] | Combination of 19 miRNAs and 21 miRNAs associated with let-7b [8] | 31 miRNAs | 137 miRNAs from K-means analysis | ||||
|---|---|---|---|---|---|---|---|---|---|
Experimental targets | Predicted targets | Experimental targets | Predicted targets | Experimental targets | Predicted targets | Experimental targets | Predicted targets | Experimental targets | |
Pathways in cancer | 1.70E-21 | 7.16E-15 | 1.59E-17 | 4.61E-24 | 7.80E-25 | 6.62E-36 | 1.45E-15 | 8.05E-62 | 8.95E-32 |
p53 signaling pathway | 7.41E-12 | 1.27E-11 | 2.42E-14 | 5.02E-21 | 2.32E-15 | 1.59E-12 | 1.33E-19 | 3.02E-14 | 5.16E-09 |
Transcriptional misregulation in cancer | 2.36E-11 | 1.05E-05 | 0.000165 | 3.08E-08 | 4.74E-10 | 5.12E-12 | 3.53E-06 | 2.85E-10 | 5.42E-19 |
Insulin signaling pathway | 1.52E-05 | 1.34E-09 | 0.021307 | 1.34E-16 | 3.03E-06 | 1.13E-20 | 1.65E-07 | 3.68E-23 | 5.48E-13 |
Neurotrophin signaling pathway | 2.84E-05 | 1.05E-06 | 0.002062 | 2.48E-25 | 4.91E-07 | 4.26E-19 | 2.07E-06 | 1.66E-24 | 4.17E-12 |
TGF-beta signaling pathway | 0.001486 | 2.28E-17 | 1.41E-05 | 1.49E-20 | 3.49E-08 | 2.08E-17 | 9.88E-09 | 4.51E-20 | 6.01E-09 |
PI3K-Akt signaling pathway | 0.002453 | 1.75E-22 | 6.96E-05 | 3.83E-32 | 0.000515 | 9.23E-48 | 6.18E-07 | 1.74E-54 | 1.82E-27 |
MAPK signaling pathway | 0.019079 | 1.34E-09 | 0.024663 | 6.89E-23 | 0.006415 | 4.21E-37 | 0.006692 | 3.18E-44 | 1.00E-21 |
Cell cycle | 4.54E-38 | 3.48E-05 | 1.38E-11 | 1.64E-03 | 1.06E-37 | 7.03E-07 | 7.97E-18 | 6.10E-09 | 2.18E-14 |
HIF-1 signaling pathway | 0.000282 | 1.37E-04 | 0.000307 | 5.47E-07 | 1.41E-05 | 8.89E-11 | 3.6E-09 | 2.36E-20 | 9.94E-11 |
Progesterone-mediated oocyte maturation | 0.000609 | 5.48E-04 | 0.008724 | 4.34E-03 | 2.06E-05 | 8.33E-07 | 0.002693 | 5.87E-14 | 1.79E-07 |