Fig. 3From: Genome-wide identification of key modulators of gene-gene interaction networks in breast cancerValidation of four modularity parameters in three independent cohorts. a-d Box plots comparing the ACI score, number of nodes, number of edges, and connectivity between 973 key modulators and other genes in three independent datasets. Statistical significance was assessed by the t-test. Generally, the key modulators exhibited significantly intensified modularity in the validation datasets, suggestive of the validity of the parameters and the conservativity of modulators among cohortsBack to article page