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Table 2 Top 6 clusters of GO terms enriched in SFRP1-modulated gene interaction network

From: Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer

GO ID GO term Num. genes P-value
Cluster 1 (enrichment score: 10.71)
GO:0005578 proteinaceous extracellular matrix 75 1.68E-13
GO:0031012 extracellular matrix 78 3.84E-13
GO:0044420 extracellular matrix part 37 7.39E-11
GO:0005201 extracellular matrix structural constituent 27 2.93E-08
Cluster 2 (enrichment score: 7.13)
GO:0010033 response to organic substance 127 8.19E-12
GO:0009725 response to hormone stimulus 68 1.45E-07
GO:0048545 response to steroid hormone stimulus 42 6.50E-07
GO:0009719 response to endogenous stimulus 71 6.66E-07
GO:0043627 response to estrogen stimulus 27 4.33E-06
Cluster 3 (enrichment score: 6.56)
GO:0044421 extracellular region part 157 2.80E-12
GO:0005615 extracellular space 99 1.56E-05
GO:0005576 extracellular region 232 4.66E-04
Cluster 4 (enrichment score: 6.27)
GO:0007049 cell cycle 136 1.94E-12
GO:0022402 cell cycle process 104 6.36E-11
GO:0022403 cell cycle phase 78 7.27E-09
GO:0000279 M phase 61 6.77E-07
GO:0000278 mitotic cell cycle 66 9.25E-07
Cluster 5 (enrichment score: 5.80)
GO:0000226 microtubule cytoskeleton organization 36 2.82E-07
GO:0007017 microtubule-based process 49 2.81E-06
GO:0007010 cytoskeleton organization 72 5.08E-06
Cluster 6 (enrichment score: 5.77)
GO:0030198 extracellular matrix organization 32 5.00E-09
GO:0043062 extracellular structure organization 34 2.52E-05
GO:0030199 collagen fibril organization 12 4.00E-05
  1. Clusters with more than five GO terms are represented by the most significant five