Skip to main content

Table 3 Top 6 clusters of GO terms enriched in the 973 modulator genes

From: Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer

GO ID GO term Num. genes P-value
Cluster 1 (enrichment score: 5.59)
GO:0042110 T cell activation 26 5.08E-08
GO:0045321 leukocyte activation 38 5.64E-08
GO:0046649 lymphocyte activation 33 1.37E-07
GO:0001775 cell activation 41 2.14E-07
GO:0002521 leukocyte differentiation 23 5.96E-06
Cluster 2 (enrichment score: 5.29)
GO:0006952 defense response 66 1.70E-06
GO:0006954 inflammatory response 42 2.16E-06
GO:0009611 response to wounding 55 3.64E-05
Cluster 3 (enrichment score: 3.60)
GO:0007155 cell adhesion 66 1.03E-04
GO:0022610 biological adhesion 66 1.08E-04
GO:0016337 cell-cell adhesion 30 1.42E-03
Cluster 4 (enrichment score: 3.39)
GO:0046635 positive regulation of alpha-beta T cell activation 11 9.27E-07
GO:0046634 regulation of alpha-beta T cell activation 12 3.69E-06
GO:0002684 positive regulation of immune system process 33 7.56E-06
GO:0051249 regulation of lymphocyte activation 24 1.39E-05
GO:0070665 positive regulation of leukocyte proliferation 14 1.41E-05
Cluster 5 (enrichment score: 3.28)
GO:0050727 regulation of inflammatory response 15 1.04E-04
GO:0048584 positive regulation of response to stimulus 30 1.06E-04
GO:0050729 positive regulation of inflammatory response 9 2.31E-04
GO:0032101 regulation of response to external stimulus 21 8.89E-04
GO:0032103 positive regulation of response to external stimulus 12 1.03E-03
Cluster 6 (enrichment score: 3.07)
GO:0010033 response to organic substance 68 7.95E-05
GO:0043627 response to estrogen stimulus 18 1.07E-04
GO:0048545 response to steroid hormone stimulus 26 1.24E-04
GO:0009725 response to hormone stimulus 36 2.60E-03
GO:0009719 response to endogenous stimulus 36 1.18E-02
  1. Clusters with more than five GO terms are represented by the most significant five