Table 3 Top 6 clusters of GO terms enriched in the 973 modulator genes
From: Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer
GO ID | GO term | Num. genes | P-value |
|---|---|---|---|
Cluster 1 (enrichment score: 5.59) | |||
GO:0042110 | T cell activation | 26 | 5.08E-08 |
GO:0045321 | leukocyte activation | 38 | 5.64E-08 |
GO:0046649 | lymphocyte activation | 33 | 1.37E-07 |
GO:0001775 | cell activation | 41 | 2.14E-07 |
GO:0002521 | leukocyte differentiation | 23 | 5.96E-06 |
Cluster 2 (enrichment score: 5.29) | |||
GO:0006952 | defense response | 66 | 1.70E-06 |
GO:0006954 | inflammatory response | 42 | 2.16E-06 |
GO:0009611 | response to wounding | 55 | 3.64E-05 |
Cluster 3 (enrichment score: 3.60) | |||
GO:0007155 | cell adhesion | 66 | 1.03E-04 |
GO:0022610 | biological adhesion | 66 | 1.08E-04 |
GO:0016337 | cell-cell adhesion | 30 | 1.42E-03 |
Cluster 4 (enrichment score: 3.39) | |||
GO:0046635 | positive regulation of alpha-beta T cell activation | 11 | 9.27E-07 |
GO:0046634 | regulation of alpha-beta T cell activation | 12 | 3.69E-06 |
GO:0002684 | positive regulation of immune system process | 33 | 7.56E-06 |
GO:0051249 | regulation of lymphocyte activation | 24 | 1.39E-05 |
GO:0070665 | positive regulation of leukocyte proliferation | 14 | 1.41E-05 |
Cluster 5 (enrichment score: 3.28) | |||
GO:0050727 | regulation of inflammatory response | 15 | 1.04E-04 |
GO:0048584 | positive regulation of response to stimulus | 30 | 1.06E-04 |
GO:0050729 | positive regulation of inflammatory response | 9 | 2.31E-04 |
GO:0032101 | regulation of response to external stimulus | 21 | 8.89E-04 |
GO:0032103 | positive regulation of response to external stimulus | 12 | 1.03E-03 |
Cluster 6 (enrichment score: 3.07) | |||
GO:0010033 | response to organic substance | 68 | 7.95E-05 |
GO:0043627 | response to estrogen stimulus | 18 | 1.07E-04 |
GO:0048545 | response to steroid hormone stimulus | 26 | 1.24E-04 |
GO:0009725 | response to hormone stimulus | 36 | 2.60E-03 |
GO:0009719 | response to endogenous stimulus | 36 | 1.18E-02 |