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Fig. 8 | BMC Genomics

Fig. 8

From: Transcriptional analysis of abdominal fat in chickens divergently selected on bodyweight at two ages reveals novel mechanisms controlling adiposity: validating visceral adipose tissue as a dynamic endocrine and metabolic organ

Fig. 8

Gene network showing interactions of two ligand-activated transcription factors (VDR and SREBF1) from RNA-Seq analysis of abdominal fat in HG and LG cockerels at 7 wk. (a). This network of 30 DE genes was functionally annotated by IPA as “Energy Production; Lipid Metabolism”. The expression of 13 DE genes was higher in abdominal fat of HG cockerels, while 17 DE genes were more abundant in the LG. Panel b provides 16 direct targets of VDR, and VDR itself, which were largely up-regulated in LG abdominal fat at 7 wk., only three genes were expressed higher in the HG. Upstream Regulator Analysis predicted inhibition of the VDR gene (blue symbol) and inhibition (blue arrow or blunt lines) of target genes reflecting its up-regulation in the LG

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BMC Genomics

ISSN: 1471-2164

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