Table 2 IPA summary of microarray analysis of abdominal fat in HG and LG cockerels (1-11 wk)
Top Canonical Pathways | p-value | Overlap | Ratio |
|---|---|---|---|
Oxidative Phosphorylation | 7.88E-10 | 17.4% | 19/109 |
Mitochondrial Dysfunction | 1.37E-08 | 12.9% | 22/171 |
EIF2 Signaling | 2.33E-07 | 11.4% | 21/185 |
NRF2-mediated Oxidative Stress Response | 2.84E-06 | 10.6% | 19/180 |
Phagosome maturation | 7.93E-05 | 10.8% | 13/120 |
Top Upstream Regulators | p-value of overlap | # Target genes | |
TP53 | 2.92E-21 | 105 | |
PPARA | 1.46E-18 | 50 | |
MYC | 2.75E-16 | 78 | |
PPARG | 1.94E-14 | 45 | |
MYCN | 2.51E-13 | 32 | |
Top Molecular and Cellular Functions | p-value | # Genes | |
Cellular Growth and Proliferation | 1.96E-04 - 1.11E-16 | 285 | |
Cellular Movement | 2.13E-04 - 3.09E-14 | 171 | |
Lipid Metabolism | 2.79E-04 - 7.14E-13 | 129 | |
Molecular Transport | 2.72E-04 - 7.14E-13 | 176 | |
Small Molecule Biochemistry | 2.79E-04 - 7.14E-13 | 163 | |
Physiological System Development and Function | p-value | # Genes | |
Cardiovascular System | 2.58E-04 - 7.81E-12 | 107 | |
Organismal Development | 2.58E-04 - 7.81E-12 | 181 | |
Organismal Survival | 4.90E-05 - 3.31E-10 | 175 | |
Hematological System | 2.72E-04 - 3.05E-08 | 123 | |
Immune Cell Trafficking | 2.72E-04 - 3.05E-08 | 72 | |
Top Up-regulated genes | HG/LG Ratio | Top Down-regulated genes | HG/LG Ratio |
FN1 | 12.58 | TGM2 | −5.86 |
SCD | 10.69 | MED27 | −5.06 |
PPP1R9A | 9.23 | SESTD1 | −4.07 |
XYLT2 | 5.14 | ALB | −3.80 |
PIGC | 4.52 | RPL18A | −3.78 |
NFASC | 4.02 | MT-ND1 | −3.21 |
PLEC | 3.55 | HSD11B1 | −3.11 |
ABHD3 | 3.40 | BM2 | −3.00 |
FASN | 3.34 | TAGLN | −2.95 |
ARID4B | 3.30 | ANGPTL3 | −2.94 |