A molecular view of the normal human thyroid structure and function reconstructed from its reference transcriptome map

Table 4 Predicted housekeeping genes from the thyroid transcriptome map (explanation in the text); (n = 45)

Gene symbol	Chromosome	Location	Expression value	Data points	SD
Hs.670607	chr4	N/A	232.70	18	11.95
BLOC1S2	chr10	10q24.31	181.44	22	13.39
Hs.706927	chr6	N/A	357.37	18	13.82
TMEM256	chr17	17p13.1	153.91	22	18.35
POM121C	chr7	7q11.2	347.50	20	22.49
CUEDC2	chr10	10q24.32	210.93	31	22.83
RPLP0*	chr12	12q24.2	3,340.82	76	23.40
PJA1	chrX	Xq13.1	234.54	31	23.83
Hs.713747	chr1	N/A	169.93	18	23.92
RAB25	chr1	1q22	199.48	31	24.00
CIB1	chr15	15q25.3-q26	314.61	33	25.01
MRPL18	chr6	6q25.3	182.80	23	25.09
SCAMP3	chr1	1q21	152.98	33	25.11
Hs.633993	chr8	N/A	2,050.15	18	25.21
Hs.714416	chr3	N/A	100.67	18	25.31
RBM23	chr14	14q11.2	257.95	31	25.67
Hs.117688	chr8	N/A	160.32	22	25.73
Hs.546523	chr2	N/A	178.40	18	25.96
DCXR	chr17	17q25.3	210.53	31	25.98
Hs.193784	chr3	N/A	491.90	22	26.02
ABRACL	chr6	6q24.1	116.71	23	26.15
MAP1LC3B2	chr12	12q24.22	157.45	18	26.29
DGCR6	chr22	22q11	209.18	20	26.31
GTPBP6	chrX; chrY	Xp22.33; Yp11.32	120.83	23	26.61
AIMP2	chr7	7p22	181.19	43	26.84
CSNK2B	chr6	6p21.3	337.74	25	26.89
TM2D2	chr8	8p11.22	256.54	28	27.09
CLIC1	chr6	6p21.3	530.89	25	27.21
Hs.715132	chrX	N/A	196.12	22	27.42
Hs.732277	chr19	N/A	218.68	22	28.49
Hs.705664	chr7	N/A	1,167.55	18	28.62
NMRAL1	chr16	16p13.3	110.71	45	28.70
Hs.713819	chr5	N/A	241.81	18	28.93
RPP21	chr6	6p22.1	111.91	23	28.94
PNMA1	chr14	14q24.3	148.75	23	28.94
ACTG1*	chr17	17q25	3,583.46	180	29.06
AKR1B1	chr7	7q35	258.94	25	29.09
APOA1BP	chr1	1q21	231.69	32	29.35
MRPL24	chr1	1q23.1	183.95	31	29.44
ABCF1	chr6	6p21.33	123.95	25	29.56
ZNF627	chr19	19p13.2	112.37	24	29.70
METRNL	chr17	17q25.3	175.03	22	29.78
OCIAD2	chr4	4p11	286.18	20	29.92
EIF2B2	chr14	14q24.3	248.05	33	29.94
DIABLO	chr12	12q24.31	211.60	31	29.98

Genes are sorted in ascending order of SD as percentage of the mean value. *In bold, the two best genes at behaving like a housekeeping gene due to a combination of a low SD, a high expression value and a high number of data points, following checking in the “Values A” TRAM table that the 180 (ACTG1) and 76 (RPLP0) data points are derived from 33 and 22 samples, respectively, out of the 35 thyroid samples analyzed. N/A: not available in the Gene database (http://www.ncbi.nlm.nih.gov/gene) when the analysis was performed

ISSN: 1471-2164