TY - JOUR AU - Boulund, Fredrik AU - Berglund, Fanny AU - Flach, Carl-Fredrik AU - Bengtsson-Palme, Johan AU - Marathe, Nachiket P. AU - Larsson, DG Joakim AU - Kristiansson, Erik PY - 2017 DA - 2017/09/02 TI - Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets JO - BMC Genomics SP - 682 VL - 18 IS - 1 AB - Fluoroquinolones are broad-spectrum antibiotics used to prevent and treat a wide range of bacterial infections. Plasmid-mediated qnr genes provide resistance to fluoroquinolones in many bacterial species and are increasingly encountered in clinical settings. Over the last decade, several families of qnr genes have been discovered and characterized, but their true prevalence and diversity still remain unclear. In particular, environmental and host-associated bacterial communities have been hypothesized to maintain a large and unknown collection of qnr genes that could be mobilized into pathogens. SN - 1471-2164 UR - https://doi.org/10.1186/s12864-017-4064-0 DO - 10.1186/s12864-017-4064-0 ID - Boulund2017 ER -