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Table 2 Assembled putatively novel qnr sequences discovered in metagenomic datasets

From: Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets

Source data set Identifier Assembled sequence length (aa) Average measured MIC (mg/L) Most similar plasmid-mediated qnr Identity with most similar pm-qnr (%) Best match in Genbank (% identity) Comment
Human microbiomes [43] HMP 1 206 - QnrB10 and QnrB62 97.04 AFY16910.1(98%) Possible misassembly: Stop codon in position 30
WWTP [54] WWTP 1 207 - QnrB15 61.76 WP_056930987.1(94%)  
WWTP [54] WWTP 2 220 - QnrA3 47.93 WP_025325370.1(95%) 10 aa difference to chromosomal variant
WWTP [54] WWTP 3a 220 - QnrA3 47.93 WP_005328535.1(100%) Identical to sequence in Genbank
WWTP [54] WWTP 4a 219 - QnrA3 46.76 WP_041212172.1(100%) Identical to sequence in Genbank
Antibiotic-polluted Indian lake [55] Lake 1a 220 - QnrVC4 99.54 WP_000361703.1(100%) Identical to sequence in Genbank
Antibiotic-polluted Indian river sediment [56] APRS 1a 220 - QnrVC4 99.54 WP_000361703.1(100%) Identical to sequence in Genbank; Lake 1
Antibiotic-polluted Indian river sediment [56] APRS 2 207 - QnrA3 47.06 WP_041212172.1(99%) Missing start codon
Indian well water [35] Well 1a 220 - QnrVC4 99.54 WP_000361703.1(100%) Identical to sequence in Genbank
Oil spill [57] Oilspill 1 220 0.037 QnrVC1 65.44 WP_019613380.1 (82%)  
Oil spill [57] Oilspill 2 220 0.025 QnrVC1 64.98 WP_019613380.1 (80%)
Oil spill [57] Oilspill 3 220 0.034 QnrVC1 62.21 WP_057181431.1(77%)
Pune river sediments [58] Pune 1 217 - QnrB27 62.15 WP_056930987.1(95%)
Pune river sediments [58] Pune 2 219 - QnrA3 47.69 WP_005340643.1(99%) 1 aa difference to chromosomal variant
Pune river sediments [58] Pune 3 220 - QnrA3 49.77 WP_044798915.1(99%) 3 aa difference to AhQnr
Pune river sediments [58] Pune 4a 219 - QnrA3 46.76 WP_042864588.1(100%) Identical to sequence in Genbank
Wadden sea [59] Wadden 1 220 0.16 QnrVC5 73.73 WP_036748004.1(76%)  
Wadden sea [59] Wadden 2 220 - QnrVC6 73.73 WP_007624600.1(75%)
Wadden sea [59] Wadden 3 219 0.029 QnrA6 62.96 WP_009385382.1(77%)
Wadden sea [59] Wadden 4 219 0.014 QnrVC7 66.67 WP_009385382.1(76%)
Wadden sea [59] Wadden 5 220 0.073 QnrA3 57.14 WP_006228785.1(66%)
Tara oceans [60] Tara 1a 219 - QnrVC1 60.65 WP_005374358.1(100%) Identical to sequence in Genbank
Tara oceans [60] Tara 2 222 0.045 QnrA3 52.29 WP_045976340.1(60%)  
Tara oceans [60] Tara 3 220 0.032 QnrVC5 53.46 WP_012534242.1(58%)  
Tara oceans [60] Tara 4 223 - QnrS2 32.57 BAH90541.1(49%)  
Tara oceans [60] Tara 5 220 - QnrA2 32.72 EPJ45142.1(38%)  
Tara oceans [60] Tara 6 221 - QnrA3 31.19 EPJ45142.1(37%)  
  1. aAssembled sequence identical to already existing sequence in Genbank