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Fig. 5 | BMC Genomics

Fig. 5

From: Transcriptome analysis reveals differences in mechanisms regulating cessation of luteal function in pregnant and non-pregnant dogs

Fig. 5

Cytoscape analysis of GO for the contrast “luteal regression over luteolysis” is presented. The functional terms overrepresented in each of the groups are shown. As input differentially expressed genes (DEG) were used (threshold was set at p < 0.01, FDR < 0.1). The redundant and non-informative terms were removed, and the resulting network was manually rearranged. For each network the size of the node implies the number of genes, while the color intensity denotes the level of enrichment (see legend to illustration). Functional networks, which were more highly represented in the luteal regression group (a), refer predominantly to matrix remodeling, to the steroid hormone signaling pathway and to cAMP-mediated signaling. Networks more highly represented during prepartum luteolysis (b) were associated to immune system, inflammatory response and regulation of apoptotic signaling

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