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Fig. 6 | BMC Genomics

Fig. 6

From: Transcriptome analysis reveals differences in mechanisms regulating cessation of luteal function in pregnant and non-pregnant dogs

Fig. 6

Cytoscape analysis of GO for the contrast “luteolysis over antigestagen” is presented. The functional terms overrepresented in each of the groups are shown. As input differentially expressed genes (DEG) were used (threshold was set at p < 0.01, FDR < 0.1). The redundant and non-informative terms were removed, and the resulting network was manually rearranged. For each network the size of the node implies the number of genes, while the color intensity denotes the level of enrichment (see legend to illustration). a The more highly represented functional networks for the prepartum luteolysis group include, e.g., response to wounding, defense response, positive regulation of cellular process, cytoskeleton organization and apoptotic signaling, as well as cell death. b The functional networks more represented in the antigestagen-treated group refer, e.g., to the negative regulation of transcription and networks relating to response to TGFβ

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