Table 1 Top cellular pathways and functions associated with liver development in chickens

E18-E20

protein ubiquitination pathway; unfolded protein response; purine nucleotides de Novo Biosynthesis II; FXR/RXR Activation; Aryl hydrocarbon Receptor signaling

TP53; beta-estradiol; XBP1; PPARA; HNF4A

cell death and survival; cellular growth and proliferation; amino acid metabolism; small molecule biochemistry; lipid metabolism

organismal survival; digestive system development and function; organ morphology; connective tissue development and function

E20-D0

FXR/RXR activation; LXR/RXR activation; LPS/IL-1 mediated inhibition of RXR function; acute phase response signaling; coagulation system

TP53; PPARA; beta-estradiol; methylprednisolone; MYC

lipid metabolism; small molecule Biochemistry; molecular transport; cell death and survival; amino acid metabolism

organismal survival; digestive system development and function; hepatic system development and function; organ morphology; organismal development

D0-D1

EIF2 signaling; LPS/IL-1 mediated inhibition of RXR function; mitochondrial dysfunction; acute phase response signaling; FXR/RXR activation

PPARA; HNF4A; methylprednisolone; pirinixic acid; MYC

amino acid metabolism; small molecule biochemistry; lipid metabolism; molecular transport; carbohydrate metabolism

digestive system development and function; hepatic system development and function; organ morphology; organismal development; tissue morphology

D1-D3

Super pathway of cholesterol biosynthesis; cholesterol biosynthesis I; cholesterol biosynthesis II (via 24, 25-dihydrolanosterol); cholesterol biosynthesis III (via Desmosterol); mitochondrial dysfunction

PPARA; SREBF1; SCAP; POR; SREBF2

lipid metabolism; molecular transport; small molecule biochemistry; vitamin and mineral metabolism; energy production

digestive system development and function; hepatic system development and function; organ morphology; organismal development; connective tissue development and function