Fig. 6

Transcriptional regulators controlling C. albicans DEGs during neutrophil/NET infection. DEGs of C. albicans during encounter of neutrophils or NET challenge were classified and visualized according to their control by transcriptional regulators, focusing on Efg1p (blue), Tup1p (red), Hap43p (green), and Cap1p (orange). a Candida genes from the GO enriched processes during neutrophil infection shown in Fig. 5c which were commonly induced or repressed; 28 induced genes in upper group, 16 repressed genes in lower group. b Percentage killing of C. albicans challenged for 1 h with human neutrophils (MOI 1). Viability of C. albicans was determined using a luciferase-based ATP assay. Shown is a representative experiment in triplicate from 2 experiments in total with very similar results, n = 2 (3). Statistical analysis was performed using a One-way ANOVA with Dunett’s post-test with ** = p < 0.01 and **** = p < 0.0001. c All morphology-dependently expressed Candida genes during neutrophil infection shown in in Fig. 5a and b; six hypha-induced genes in upper group, 13 hypha-repressed genes in lower group. d Candida genes from the GO enriched processes during NET challenge shown in Fig. 7c which were commonly induced or repressed; six induced genes in upper group, 43 repressed genes in lower group. e All morphology-dependently expressed Candida genes during NET challenge shown in Fig. 7a and b; four hypha-induced genes in upper left group, four hypha-repressed genes in lower left group, seven yeast-induced genes in upper right group, two yeast-repressed genes in lower right group