Fig. 7

Transcriptional response of C. albicans challenged by NETs. Candida genes differentially expressed in yeasts and hyphae upon NET encounter were considered. DEGs were grouped according to their transcript profile at 15 min to 60 min p.i. in yeast and hypha (A + B): Genes are called commonly repressed or induced in both morphotypes if in at least one time point in one morphotype a significant differential expression was detected (≥ 4 fold) and in the other morphotype a regulation of ≥ 2-fold towards was given at any time point (a). Genes are called induced or repressed in hyphae but not in yeast (and vice-a-versa) if in at least one time point in hyphae or yeast a significant differential expression was detected (≥ 4-fold) and no regulation ≥ 2-fold was given at any time point for the other morphotype (b and c). c Corresponding sets of up- and down-regulated genes were mapped with the “GO term finder” at CGD (http://www.candidagenome.org/cgi-bin/GO/goTermFinder) to biological processes. Beside the assessment of the statistical significance of the gene set with a calculated p-value, the X-fold enrichment is calculated as ratio of percentages of the cluster frequency of tested gene set and the cluster frequency of genomic background. Red indicates up-regulation, blue indicates down-regulation. Samples from two independent experiments using different blood donors were analyzed, n = 2