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Table 3 The top ten most overrepresented Biological Functions in each species, determined using g:Cocoa

From: Patterns of host gene expression associated with harboring a foregut microbial community

Function GO Term No. genes in term No. genes overexpressed in woodrats No. genes overexpressed in lab rats
Overrepresented in woodrats
 Cellular component organization GO:0016043 5139 347 252
 Metabolic process GO:0008152 11,355 638 580
 Actin cytoskeleton organization GO:0030036 520 65 18
 Intracellular signal transduction GO:0035556 2241 176 1
 Cellular component morphogenesis GO:0032989 1204 112 29
 Regulation of multicellular organismal process GO:0051239 2423 175 62
 Regulation of molecular function GO:0065009 2460 174 61
 Regulation of intracellular signal transduction GO:1,902,531 1417 107 1
 Cell migration GO:0016477 1081 53 55
 Muscle contraction GO:0006936 240 25 3
Overrepresented in lab rats
 Single-organism metabolic process GO:0044710 4526 265 305
 Immune response GO:0006955 1107 10 69
 Defense response GO:0006952 1264 20 65
 Organic hydroxy compound metabolic process GO:1,901,615 431 22 43
 Positive regulation of cell activation GO:0050867 250 8 21
 Positive regulation of T cell activation GO:0050870 155 5 16
 Neutrophil migration GO:1,990,266 94 1 11
 Nuclear DNA replication GO:0033260 15 1 6
 L-serine biosynthetic process GO:0006564 4 0 4
 Localization GO:0051179 5203 289 305
  1. Corrected p-values are all less than 0.001. We used the moderate filtering to first identify the most differentially represented term per parent group