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Fig. 1 | BMC Genomics

Fig. 1

From: Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation

Fig. 1

Rat tissue-specific DMRs (tsDMRs) and their orthologous regions in mouse and human. a Numbers of rat tissue-specific hypomethylated tsDMRs ( Methods ) (middle purple panel), and percentage of rat tsDMRs with orthologous regions in mouse (left panel) and human (right panel) genomes, respectively. A chi-square test was performed to obtain p-values by comparing tsDMRs with genomic annotation matched random control regions in each respective tissue type. P-values were corrected for multiple testing using the Benjamini–Hochberg FDR method. b Genome-wide methylation profile of rat tsDMRs and orthologous regions in mouse and human. The left column shows the methylation profiles of rat tsDMRs in each of the three rat tissue types; the middle column shows the methylation profiles of mouse orthologous regions of rat tsDMRs in each of the mouse tissue types; and the right column shows the methylation profile of human orthologous regions of rat tsDMRs in each of the human tissue types

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