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Fig. 4 | BMC Genomics

Fig. 4

From: Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation

Fig. 4

TF motif analysis of rat tsDMRs and their orthologous regions in mouse and human. a Heatmaps representing the enrichment of transcription factor binding motifs for brain and blood tsDMRs the orthologous regions of these tsDMRs. Left panel: motif enrichment for rat-mouse comparison; right panel: motif enrichment for rat-human comparison. b Motif enrichment (fold change) of the top 10 TFBSs in rat blood (top row) and rat brain (bottom row) (as defined by the HOMER enrichment), separated by their epigenetic conservation status (Methods). First two columns: rat-mouse comparison; last two columns: rat-human comparison. A t-test was performed to obtain p-values. P-values were corrected for multiple testing using the Benjamini–Hochberg FDR method

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BMC Genomics

ISSN: 1471-2164

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