Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation

Table 1 tsDMRs by epigenetic conservation status (2-way analysis)

The percentage in parenthesis is calculated as the number of epigenetically conserved tsDMRs divided by the number of tsDMRs for each tissue type. A hypergeometric test was performed to determine if the epigenetic conservation was significant. The number of ‘observed’ epigenetically conserved tsDMRs is indicated in the ‘EC’ column. The number of ‘expected’ epigenetically conserved tsDMRs was determined by randomly selecting 40,000 rat regions and examining the number of these randomly picked regions that were epigenetically conserved between rat and mouse/human
A hypergeometric test was performed to obtain p-values. P-values were corrected for multiple testing using the Benjamini–Hochberg FDR method
EC Epigenetically conserved
ENC Epigenetically non-conserved

ISSN: 1471-2164