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Table 2 Summary of overlap between histone mark peaks and mouse and human orthologous regions of rat tsDMRs

From: Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation

Mouse

Blood

 

# tsDMRs

H3K4me1

H3K4me3

H3K27ac

H3K27me3

EC

1477

181

146

193

5

ENC

3583

282

86

145

16

p-value

 

8.77E-07

5.67E-31

1.54E-31

0.587

Brain

EC

2508

826

70

551

18

ENC

4037

801

44

269

19

p-value

 

9.85E-33

3.15E-07

6.73E-74

0.195

Sperm

EC

11,149

3690

1889

559

334

ENC

22,040

1941

555

314

155

p-value

 

0

0

5.62E-83

3.02E-60

Human

Blood

EC

629

311

138

221

24

ENC

2786

346

77

197

117

p-value

 

1.84E-100

1.57E-71

8.21E-84

0.662

Brain

EC

872

272

207

250

33

ENC

4424

992

429

710

180

p-value

 

2.82E-08

2.09E-31

9.40E-19

0.696

  1. Overlap between a histone mark peak and a mouse/human orthologous region was defined if the orthologous region contained the summit of the histone mark peak
  2. A chi-square test was performed to obtain p-values. P-values were corrected for multiple testing using Benjamini–Hochberg FDR method
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BMC Genomics

ISSN: 1471-2164

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