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Table 2 Top 20 CLL risk-related DM CpG sites; based on comparison of all cases vs controls with <10% B-cells, with adjustment for WBC composition

From: Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis

CpG site Gene symbol Raw p-value FDR BH LSM β, controls (%) LSM β, cases (%) Δβ = cases-controls (%)
cg05677184   <1E-99 1.11E-18 83.2 76.08 −7.12
cg10318725 RASA3 <1E-99 3.10E-17 87.09 79.18 −7.92
cg04308797 SEC14L1 <1E-99 2.10E-16 86.78 66.71 −20.07
cg20649847 ANKRD13B <1E-99 4.86E-15 88.38 57.93 −30.45
cg04099036 TBCD <1E-99 8.64E-15 87.7 74.77 −12.93
cg25212453 SLC43A2 <1E-99 8.64E-15 0.7 1.52 −10.46
cg15909319   1.06E-19 8.64E-15 87.88 77.42 0.82
cg09640070 ITPR2 <1E-99 8.33E-14 83.63 76.69 −6.94
cg19172447 EP400 <1E-99 8.33E-14 88.63 78.61 −10.01
cg06475633 P2RX1 <1E-99 3.60E-13 97.09 92.59 −4.51
cg07508446   <1E-99 4.83E-13 79.74 75.52 −4.22
cg08461425 KDM2B <1E-99 6.63E-13 80.63 73.99 −6.64
cg05698911 DUSP22 <1E-99 1.74E-12 81.93 74.79 −7.14
cg19907483 RFX2 <1E-99 2.89E-12 90.14 83.67 −6.46
cg01595262   2.22E-16 4.10E-12 82.37 76.17 −6.2
cg21394039 ATP9B 2.22E-16 4.10E-12 85.79 79.99 −5.79
cg01438467 SLC43A2 2.22E-16 6.00E-12 89.59 83.93 −5.66
cg03777414 TVP23A 4.44E-16 9.68E-12 79.21 67.17 −12.04
cg14972228 SIPA1L3 8.88E-16 1.57E-11 82.02 77.19 −4.83
cg26363196 ST6GALNAC3 8.43E-16 1.76E-11 2.53 3.75 1.22