Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis

Table 2 Top 20 CLL risk-related DM CpG sites; based on comparison of all cases vs controls with <10% B-cells, with adjustment for WBC composition

CpG site	Gene symbol	Raw p-value	FDR BH	LSM β, controls (%)	LSM β, cases (%)	Δβ = cases-controls (%)
cg05677184		<1E-99	1.11E-18	83.2	76.08	−7.12
cg10318725	RASA3	<1E-99	3.10E-17	87.09	79.18	−7.92
cg04308797	SEC14L1	<1E-99	2.10E-16	86.78	66.71	−20.07
cg20649847	ANKRD13B	<1E-99	4.86E-15	88.38	57.93	−30.45
cg04099036	TBCD	<1E-99	8.64E-15	87.7	74.77	−12.93
cg25212453	SLC43A2	<1E-99	8.64E-15	0.7	1.52	−10.46
cg15909319		1.06E-19	8.64E-15	87.88	77.42	0.82
cg09640070	ITPR2	<1E-99	8.33E-14	83.63	76.69	−6.94
cg19172447	EP400	<1E-99	8.33E-14	88.63	78.61	−10.01
cg06475633	P2RX1	<1E-99	3.60E-13	97.09	92.59	−4.51
cg07508446		<1E-99	4.83E-13	79.74	75.52	−4.22
cg08461425	KDM2B	<1E-99	6.63E-13	80.63	73.99	−6.64
cg05698911	DUSP22	<1E-99	1.74E-12	81.93	74.79	−7.14
cg19907483	RFX2	<1E-99	2.89E-12	90.14	83.67	−6.46
cg01595262		2.22E-16	4.10E-12	82.37	76.17	−6.2
cg21394039	ATP9B	2.22E-16	4.10E-12	85.79	79.99	−5.79
cg01438467	SLC43A2	2.22E-16	6.00E-12	89.59	83.93	−5.66
cg03777414	TVP23A	4.44E-16	9.68E-12	79.21	67.17	−12.04
cg14972228	SIPA1L3	8.88E-16	1.57E-11	82.02	77.19	−4.83
cg26363196	ST6GALNAC3	8.43E-16	1.76E-11	2.53	3.75	1.22

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