Skip to main content
Fig. 4 | BMC Genomics

Fig. 4

From: A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer

Fig. 4

Network based on a restricted number of genes after selection of topological parameters. a Network based on 57 genes showing a node degree superior to 11 (median of node degree of 111 genes-based network). b Network based on 32 genes showing a node degree superior to 11 and a clustering coefficient superior to 0.55 (median of clustering coefficient of 111 genes-based network). Blue color of edges indicated a physical interaction between 2 nodes. The thickness of edges was correlated with the score confidence (large for a high score). The node shape illustrated the specific PCR array: Apoptosis: square, Cancer Pathway: hexagon, Lipoprotein signaling and cholesterol metabolism: circles, Drug metabolism: diamond and Wnt pathway: octagon. The color intensity of nodes was related to transcriptome deregulation (red for up-regulation and green for down-regulation in CRC as compared to NT). Genes showing a deregulation in more than 75% of CRC were characterized by bold line of shape node

Back to article page