Table 5 The pathways and key proteins and metabolites for breast muscle in Cobb chickens^a

FXR/RXR Activation, LXR/RXR Activation

APOB, SERPINA1, COL3A1, FGA

LYZ, APOA1, APOH, androsterone

ALB, TF, APOH, GC, androsterone

Calcium Signaling

MYH2, TNNI2, acetylcholine, TPM1, CASQ2, ACTA1

TNNI2, TNNC2, TNNC1, TPM1, ATP2A2, CASQ2

MYH2, acetylcholine, TNNC1

Actin Cytoskeleton Signaling

TLN2, MYH2, MYL10, acetylcholine, TLN1, ACTA1

FN1, FLNA, ACTN2

MYH2, acetylcholine, ARPC3, GSN

Glycolysis I/ Gluconeogenesis I

ENO1, MDH2

PGAM1, MDH1, MDH2

PGK1, GPI, PGAM1, GAPDH, FBP2

TCA Cycle II (Eukaryotic)

ACO2, DLD, FH, MDH2

ACO2, MDH1, FH, MDH2, OGDH

–

Oxidative Phosphorylation/ Mitochondrial Dysfunction

NDUFS1, ATP5B, UQCRC2, ACO2, VDAC1, palmitic acid, VDAC2

ATP5B, ACO2, NDUFB6, OGDH, palmitic acid, ATP5F1, VDAC2

Hepatic Fibrosis / Hepatic Stellate Cell Activation

MYH2, COL6A1, COL6A2, COL20A1, COL3A1

–

MYH2, COL4A1, COL12A1

Acute Phase Response Signaling

–

FN1, APOA1, APOH

ALB, TF, APOH

Protein Kinase A Signaling

–

prostaglandin E2, TNNI2, FLNA, PDIA3, PYGB

prostaglandin E2, PHKB, MYH2, YWHAE, YWHAZ, PYGB

Clathrin-mediated Endocytosis Signaling

–

SH3GL1, LYZ, APOA1

ALB, TF, ARPC3