Genomic regions associated with host response to porcine reproductive and respiratory syndrome vaccination and co-infection in nursery pigs

Table 2 SNPs with significant main/interaction effects with vaccination status following PRRS vaccination and PRRSV/PCV2b co-infection

Infection Period	Trait	Effect^a	SNP Name	Chromosome	Mb^b	P-value^c
Post Vaccination	ADG^d	Main	ALGA0036437	6	108	7.7
			ALGA0107326	7	81	6.1
			MARC0056209	7	81	5.6
			ALGA0042683	7	82	5.6
			WU_10.2_17_32849954	17	32	6.9
			WU_10.2_18_4027654	18	4	6.3
			WU_10.2_18_4233046	18	4	6.1
		Interaction	ASGA0077518	17	57	5.6
Post Co-Infection	PRRS VL^e	Main	–	–	–	–
	PRRS VL^e	Interaction	–	–	–	–
	PCV2b VL	Main	DRGA0007276	7	19	6.2
			H3GA0020199	7	20	8.7
			ASGA0032282	7	32	5.5
			MARC0060135	7	41	7.3
		Interaction	–	–	–	–
	ADG	Main	MARC0021766	1	47	7.1
			MARC0059955	7	24	7.7
			WU_10.2_15_140171163	15	140	6.0
		Interaction	WU_10.2_4_6084304	4	6	5.5

^aEffect: The effect of SNP across groups vaccinated, or not, for PRRS (main) versus the effect of SNP interacting with vaccination status (interaction)
^bMb, megabase
^c P-value: -log₁₀ p-value
^dADG: calculated as the regression of body weight on dpi post PRRS vaccination and post PRRSV/PCV2b co-infection
^eVL: calculated as the area under the curve from −28 to 0, 0 to 21, or 0 to 42 dpi for vaccination VL, PRRS VL, and PCV2b VL, respectively

ISSN: 1471-2164