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Table 1 COL5A1 rs12722 and rs3196378 genotype and allele distribution of controls and athletes separated by code (RL and RU) and into positional sub-groups for RU, presented as genotype/allele counts followed by percentage in parentheses

From: COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby

Genotype

Controls

All athletes

RL athletes

RU athletes

Forwards

Backs

Back 3 and Centres

rs12722

 TT

189 (33.4)

144 (26.7)

23 (26.1)

123 (26.7)

75 (28.5)

48 (24.4)

28 (22.8)

 CT

288 (51.0)

282 (52.2)

51 (58.0)

236 (51.3)

130 (49.4)

106 (53.8)

65 (52.8)

 CC

88 (15.6)

111 (21.1)*

14 (15.9)

101 (22.0)*

58 (22.1)*

43 (21.8)*

30 (24.4)*

Total

565

540

88

460

263

197

123

T allele carriers

477 (84.4)

426 (78.9)*

74 (84.1)

359 (78.0)*

205 (77.9)*

154 (78.2)*

93 (75.6)*

C allele carriers

379 (66.5)

396 (73.3)*

65 (73.9)

337 (73.3)*

188 (71.5)

149 (75.6)*

95 (77.2)*

rs3196378

 AA

183 (32.9)

144 (26.7)

23 (26.1)

123 (26.7)

74 (28.1)

49 (24.9)

28 (22.8)

 CA

286 (51.4)

271 (50.2)

49 (55.7)

227 (49.3)

122 (46.4)

105 (53.3)

65 (52.8)

 CC

87 (15.6)

125 (23.1)*

16 (18.2)

110 (24.0)*

67 (25.5)*

43 (21.8) *

30 (24.4)*

Total

556

540

88

460

263

197

123

A allele carriers

469 (84.4)

415 (76.9)*

72 (81.8)

350 (76.1)*

196 (74.5)*

154 (78.2)*

93 (75.6)*

C allele carriers

373 (67.1)

396 (73.3)*

65 (73.9)

337 (73.3)*

189 (71.9)

148 (75.1)*

95 (77.2)*

  1. RU, rugby union, RL rugby league. The genotype, T allele carrier and C allele carrier data represent the additive, dominant model and recessive models, respectively. Eight athletes competed in both elite RL and RU and were included in both groups that were analysed separately
  2. Asterisks (*) indicate Chi-square differences from controls (P ≤ 0.03)