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Table 1 COL5A1 rs12722 and rs3196378 genotype and allele distribution of controls and athletes separated by code (RL and RU) and into positional sub-groups for RU, presented as genotype/allele counts followed by percentage in parentheses

From: COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby

Genotype Controls All athletes RL athletes RU athletes Forwards Backs Back 3 and Centres
rs12722
 TT 189 (33.4) 144 (26.7) 23 (26.1) 123 (26.7) 75 (28.5) 48 (24.4) 28 (22.8)
 CT 288 (51.0) 282 (52.2) 51 (58.0) 236 (51.3) 130 (49.4) 106 (53.8) 65 (52.8)
 CC 88 (15.6) 111 (21.1)* 14 (15.9) 101 (22.0)* 58 (22.1)* 43 (21.8)* 30 (24.4)*
Total 565 540 88 460 263 197 123
T allele carriers 477 (84.4) 426 (78.9)* 74 (84.1) 359 (78.0)* 205 (77.9)* 154 (78.2)* 93 (75.6)*
C allele carriers 379 (66.5) 396 (73.3)* 65 (73.9) 337 (73.3)* 188 (71.5) 149 (75.6)* 95 (77.2)*
rs3196378
 AA 183 (32.9) 144 (26.7) 23 (26.1) 123 (26.7) 74 (28.1) 49 (24.9) 28 (22.8)
 CA 286 (51.4) 271 (50.2) 49 (55.7) 227 (49.3) 122 (46.4) 105 (53.3) 65 (52.8)
 CC 87 (15.6) 125 (23.1)* 16 (18.2) 110 (24.0)* 67 (25.5)* 43 (21.8) * 30 (24.4)*
Total 556 540 88 460 263 197 123
A allele carriers 469 (84.4) 415 (76.9)* 72 (81.8) 350 (76.1)* 196 (74.5)* 154 (78.2)* 93 (75.6)*
C allele carriers 373 (67.1) 396 (73.3)* 65 (73.9) 337 (73.3)* 189 (71.9) 148 (75.1)* 95 (77.2)*
  1. RU, rugby union, RL rugby league. The genotype, T allele carrier and C allele carrier data represent the additive, dominant model and recessive models, respectively. Eight athletes competed in both elite RL and RU and were included in both groups that were analysed separately
  2. Asterisks (*) indicate Chi-square differences from controls (P ≤ 0.03)