Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration

Wang, Guan; Durussel, Jérôme; Shurlock, Jonathan; Mooses, Martin; Fuku, Noriyuki; Bruinvels, Georgie; Pedlar, Charles; Burden, Richard; Murray, Andrew; Yee, Brendan; Keenan, Anne; McClure, John D.; Sottas, Pierre-Edouard; Pitsiladis, Yannis P.

doi:10.1186/s12864-017-4191-7

Table 2 24 genes responded differently (significantly down-regulated over Post 1, 2, 3) in the rHuEpo group relative to the placebo group in the MDS

From: Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration

	Log2 FC			FC			Uncorrected P val.			FDR
Gene	Post 1	Post 2	Post 3	Post 1	Post 2	Post 3	Post 1	Post 2	Post 3	Post 1	Post 2	Post 3
ADIPOR1	−0.69	−1.17	−1.02	−1.61	−2.24	−2.03	0.00669	0.00001	0.00007	0.01958	0.00009	0.00048
ALAS2	−1.10	−1.78	−1.55	−2.14	−3.43	−2.93	0.00504	0.00001	0.00008	0.01720	0.00009	0.00048
BCL2L1	−0.97	−1.29	−1.12	−1.96	−2.44	−2.18	0.00269	0.00010	0.00050	0.01720	0.00026	0.00172
BPGM	−0.72	−1.11	−1.04	−1.64	−2.16	−2.05	0.00417	0.00002	0.00004	0.01720	0.00010	0.00048
CA1	−0.82	−1.28	−1.12	−1.76	−2.42	−2.18	0.01519	0.00022	0.00090	0.02967	0.00044	0.00223
CSDA	−0.80	−1.25	−1.12	−1.75	−2.39	−2.18	0.00791	0.00005	0.00022	0.01959	0.00020	0.00088
DCAF12	−0.77	−1.24	−1.05	−1.70	−2.36	−2.07	0.01941	0.00024	0.00144	0.03351	0.00045	0.00282
EPB42	−1.30	−1.76	−1.44	−2.47	−3.39	−2.72	0.00286	0.00009	0.00097	0.01720	0.00025	0.00223
FAM46C	−0.66	−1.12	−0.98	−1.58	−2.17	−1.98	0.00462	0.00000	0.00003	0.01720	0.00009	0.00048
FBXO7	−0.64	−1.02	−0.94	−1.56	−2.03	−1.91	0.00792	0.00003	0.00011	0.01959	0.00014	0.00049
FECH	−0.78	−1.20	−1.13	−1.72	−2.30	−2.18	0.00545	0.00003	0.00007	0.01720	0.00014	0.00048
GMPR	−1.06	−1.39	−1.11	−2.08	−2.62	−2.16	0.00391	0.00022	0.00249	0.01720	0.00044	0.00465
GUK1	−0.77	−1.26	−1.05	−1.71	−2.40	−2.07	0.01462	0.00010	0.00098	0.02967	0.00026	0.00223
KRT1	−1.16	−1.53	−1.22	−2.24	−2.89	−2.33	0.00181	0.00006	0.00110	0.01720	0.00021	0.00236
OSBP2	−0.78	−1.13	−0.99	−1.72	−2.19	−1.99	0.00820	0.00020	0.00086	0.01959	0.00043	0.00223
SELENBP1	−1.28	−1.68	−1.39	−2.43	−3.21	−2.62	0.00295	0.00014	0.00124	0.01720	0.00033	0.00254
SLC4A1	−1.27	−1.60	−1.37	−2.42	−3.03	−2.58	0.00860	0.00123	0.00476	0.01959	0.00209	0.00813
SNCA	−0.84	−1.47	−1.28	−1.79	−2.77	−2.42	0.00952	0.00001	0.00009	0.02054	0.00009	0.00048
STRADB	−0.85	−1.36	−1.20	−1.80	−2.56	−2.30	0.00438	0.00001	0.00006	0.01720	0.00009	0.00048
TMOD1	−0.99	−1.43	−1.22	−1.98	−2.69	−2.33	0.00303	0.00003	0.00025	0.01720	0.00014	0.00094
TNS1	−1.26	−1.63	−1.26	−2.40	−3.10	−2.39	0.00318	0.00020	0.00330	0.01720	0.00043	0.00589
TRIM58	−0.93	−1.25	−1.15	−1.91	−2.38	−2.22	0.00536	0.00027	0.00061	0.01720	0.00049	0.00181
UBXN6	−0.71	−1.23	−1.05	−1.64	−2.35	−2.07	0.01962	0.00009	0.00062	0.03351	0.00025	0.00181
YOD1	−0.59	−1.10	−1.04	−1.50	−2.14	−2.05	0.01831	0.00002	0.00004	0.03351	0.00011	0.00048

Log2 FC log2 transformed fold-change, FC fold-change, FDR false discovery rate adjusted significance

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