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Table 3 The adaptive model analysis summarising the within- and between-subject variances, sensitivity, specificity and ROC area for the HGB concentration, OFF-score and 41 transcripts analysed in the MDS

From: Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration

 

Mean

Within-subject variance

Between-subject variance

Sensitivity (%)

Specificity (%)

ROC area

HGB (g·L -1)

150

29

36

79

93

0.87

OFF-score

92

51

62

93

93

0.93

ADIPOR1

3.33

0.098

0.085

86

79

0.97

ALAS2

3.09

0.204

0.282

100

79

0.97

BCL2L1

1.33

0.159

0.202

93

93

0.96

BPGM

2.74

0.107

0.087

93

71

0.98

CA1

1.28

0.159

0.190

93

79

0.97

CCR7

−0.15

0.092

0.155

29

93

0.78

CD247

−0.66

0.059

0.046

43

71

0.62

CD3D

0.30

0.061

0.048

43

64

0.63

CSDA

2.68

0.136

0.150

93

93

0.98

DCAF12

2.18

0.146

0.198

93

79

0.98

EEF1D

1.75

0.026

0.027

43

64

0.63

EPB42

−0.91

0.243

0.448

93

86

0.96

FAM46C

3.74

0.083

0.061

93

79

0.95

FBXO7

3.54

0.079

0.075

79

79

0.92

FECH

1.34

0.142

0.119

86

71

0.95

GMPR

0.23

0.181

0.281

86

86

0.93

GUK1

0.51

0.130

0.228

86

79

0.95

GYPE

−4.87

0.145

0.282

79

93

0.92

HBD

0.20

0.243

0.885

64

64

0.95

KRT1

−1.31

0.327

1.229

86

71

0.86

LEF1

0.37

0.083

0.129

36

93

0.68

LOC100130562

2.78

0.032

0.027

50

71

0.63

LOC286444

0.73

0.034

0.049

50

79

0.69

MIF

−0.15

0.043

0.021

36

71

0.62

OSBP2

0.61

0.205

0.206

93

79

0.97

PITHD1

0.20

0.125

0.183

86

86

0.92

RBM38

0.44

0.150

0.566

79

79

0.89

RNF213

0.76

0.102

0.062

36

79

0.42

SELENBP1

0.63

0.240

0.401

93

79

0.92

SGK223

−2.81

0.064

0.042

36

79

0.60

SKAP1

−1.52

0.055

0.052

43

79

0.61

SLC4A1

1.36

0.213

0.595

93

86

0.96

SNCA

0.87

0.172

0.154

86

71

0.96

STRADB

2.29

0.136

0.145

93

86

0.99

TMOD1

−0.57

0.188

0.163

93

71

0.95

TNS1

−2.05

0.234

0.306

93

86

0.96

TPRA1

−2.43

0.011

0.010

50

79

0.67

TRIM58

2.23

0.156

0.199

86

71

0.98

UBXN6

2.06

0.107

0.209

93

71

0.98

VEGFB

−1.62

0.045

0.039

57

64

0.67

YOD1

1.48

0.137

0.050

71

71

0.90

  1. ROC receiving operating characteristic