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Table 3 The adaptive model analysis summarising the within- and between-subject variances, sensitivity, specificity and ROC area for the HGB concentration, OFF-score and 41 transcripts analysed in the MDS

From: Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration

  Mean Within-subject variance Between-subject variance Sensitivity (%) Specificity (%) ROC area
HGB (g·L -1) 150 29 36 79 93 0.87
OFF-score 92 51 62 93 93 0.93
ADIPOR1 3.33 0.098 0.085 86 79 0.97
ALAS2 3.09 0.204 0.282 100 79 0.97
BCL2L1 1.33 0.159 0.202 93 93 0.96
BPGM 2.74 0.107 0.087 93 71 0.98
CA1 1.28 0.159 0.190 93 79 0.97
CCR7 −0.15 0.092 0.155 29 93 0.78
CD247 −0.66 0.059 0.046 43 71 0.62
CD3D 0.30 0.061 0.048 43 64 0.63
CSDA 2.68 0.136 0.150 93 93 0.98
DCAF12 2.18 0.146 0.198 93 79 0.98
EEF1D 1.75 0.026 0.027 43 64 0.63
EPB42 −0.91 0.243 0.448 93 86 0.96
FAM46C 3.74 0.083 0.061 93 79 0.95
FBXO7 3.54 0.079 0.075 79 79 0.92
FECH 1.34 0.142 0.119 86 71 0.95
GMPR 0.23 0.181 0.281 86 86 0.93
GUK1 0.51 0.130 0.228 86 79 0.95
GYPE −4.87 0.145 0.282 79 93 0.92
HBD 0.20 0.243 0.885 64 64 0.95
KRT1 −1.31 0.327 1.229 86 71 0.86
LEF1 0.37 0.083 0.129 36 93 0.68
LOC100130562 2.78 0.032 0.027 50 71 0.63
LOC286444 0.73 0.034 0.049 50 79 0.69
MIF −0.15 0.043 0.021 36 71 0.62
OSBP2 0.61 0.205 0.206 93 79 0.97
PITHD1 0.20 0.125 0.183 86 86 0.92
RBM38 0.44 0.150 0.566 79 79 0.89
RNF213 0.76 0.102 0.062 36 79 0.42
SELENBP1 0.63 0.240 0.401 93 79 0.92
SGK223 −2.81 0.064 0.042 36 79 0.60
SKAP1 −1.52 0.055 0.052 43 79 0.61
SLC4A1 1.36 0.213 0.595 93 86 0.96
SNCA 0.87 0.172 0.154 86 71 0.96
STRADB 2.29 0.136 0.145 93 86 0.99
TMOD1 −0.57 0.188 0.163 93 71 0.95
TNS1 −2.05 0.234 0.306 93 86 0.96
TPRA1 −2.43 0.011 0.010 50 79 0.67
TRIM58 2.23 0.156 0.199 86 71 0.98
UBXN6 2.06 0.107 0.209 93 71 0.98
VEGFB −1.62 0.045 0.039 57 64 0.67
YOD1 1.48 0.137 0.050 71 71 0.90
  1. ROC receiving operating characteristic