Table 3 Summary of hypothesis-free studies
From: Genes to predict VO2max trainability: a systematic review
Gene | Variant | Chromosome | MapPosition | Minor allele frequency (MAF) frequency | Race | Gender | Age | Training period | Sessions/wk | Session duration | Sessions intensity | (+/−/0)** genotype/expression and VO2max response to training | P-value | Author, Date |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
^*CAMTA1 intronic | rs884736 | 1 | 6,937,692 | 0.41 | 1. 473 Caucasian 2. 259 African-American | M&F M&F | 17–65 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | AA (−) | 1. 1.49 × 10- 4 2. 0.03 3. 1.54 × 10 −4 | Bouchard, 2011 (1&2) Ghosh, 2013 (3) |
+ID3 | rs11574 (1:g.23559007 T > C c.313A > G p. Thr105Ala) | 1 | 23,758,085 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 2.1 × 10−3 | Timmons, 2010 |
*RGS18 5′ upstream of gene (non-coding) | rs10921078 (1:g.192059022G > A) | 1 | 190,325,645 | 0.15 | 1. 483 Caucasian 2. 259 African-American | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | GG (−) n = 567 | 1. 7.17 × 10~ 5 2. 0.032 | Bouchard, 2011 |
^RYR2 intronic | rs7531957 (1:g.237789656 T > G) | 1 | 235,856,279 | 0.08 | 473 Caucasian) | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | NA | 1:6.42 × 10– 5 2:1.18 × 10 −4 | Bouchard, 2011 (1) Ghosh, 2013 (2) |
#SCLC45A1 | NA | 1 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | NA | #89.1 | Ghosh, 2013 |
MAST2 | rs2236560 | 1 | 46,268,021 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
SYPL2 | rs12049330 | 1 | 109,832,711 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2.12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
#ACVR1C | NA | 2 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #85.8 | Ghosh, 2013 |
SLC4A5 | rs828902 | 2 | 74,323,642 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | NA | Timmons, 2010 |
KCNF1/NLGN1 | rs2003298 (2:g.11086150 T > C) | 2 | 11,003,601 | 0.42 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.21 × 10~4 | Bouchard, 2011 |
* FLJ44450 | rs4952535 (2:g.42131523G > A) | 2 | 41,985,027 | 0.41 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | G (+) | 1.01 × 10-4 | Bouchard, 2011 |
++TTN | rs10497520 (2:g.179644855 T > C c3601A > G p.Lys1201Glu) | 2 | 175,353,100 | 0.50 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 2.5 × 10−3 | Timmons, 2010 |
++NRP2 intronic | rs3770991 (2:g.206655739A > G) | 2 | 206,363,984 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.4 × 10−3 | Timmons, 2010 |
CREB1 | rs2709356 | 2 | 208,120,337 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | NA | Timmons, 2010 |
SCN3A | rs7574918 | 2 | 165,647,425 | NA | 473 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
^HCG22 | rs2517512 (6:g.31029685C > T) | 6 | NA | 0.18 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 3.09 × 10−5 | Ghosh, 2013 |
*KCNH8 (268 kb) | rs4973706 (3:g.18921772 T > C) | 3 | 18,896,776 | 0.24 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | A (+) | 5.31 × 10~5 | Bouchard, 2011 |
*ZIC4 (146 kb) intronic | rs11715829 | 3 | 148,439,856 | 0.08 | 1. 473 Caucasian 2. 183 Caucasian | M&F M&F | 17–65 40–65 | 20 wks 6 mths | 3×/wk. 3-4×/wk | 30–50 min 4-8 kcal/kg/week | 55–75% VO 2 max +50%VO 2 max | AA (−) n = 4 | 8.68 × 10- 6 0.032 | Bouchard, 2011 |
*NLGN1 (110 kb) intronic | rs2030398 (3:g.173005973G > A) | 3 | 174,488,667 | 0.20 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | A (+) | 1.32 × 10~4 | Bouchard, 2011 |
^ADCY | NA | 3 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #86.1 | Ghosh, 2013 |
AMOTL2 | rs13322269 | 3 | 135,569,834 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2.12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
CSN1S2B intronic | rs2272040 (4:g71007047A > G) | 4 | 71,041,636 | 0.13 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 5.05 × 10-5 | Bouchard, 2011 |
*LOC100289626 (134 kb) | rs2053896 (4:g137154796G > A) | 4 | 137,374,246 | 0.10 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | A (+) | 6.62 × 10~5 | Bouchard, 2011 |
^*ACSL1 | rs6552828 (4:g.185725416A > G) | 4 | 185,962,410 | 0.37 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | AA (−) | 1:1.31 × 10– 6 2:3.8 × 10 −6 | Bouchard, 2011 (1) Ghosh, 2013 (2) |
^SLED1 | rs6552828 | 4 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 3.8 × 10−6 | Ghosh, 2013 |
^C4orf40 | rs3775758 (4:g.71008910C > T) | 4 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.09 × 10−4 | Ghosh, 2013 |
^TEC | rs13117386 (4:g.48252763G > C) | 4 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 7.97 × 10−5 | Ghosh, 2013 |
#NLN | NA | 5 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #88 | Ghosh, 2013 |
FAABP6 | rs7734683 | 5 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.44 × 10−4 | Ghosh, 2013 |
TTC1 | rs2176830 | 5 | 159,380,714 | 0.13 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.42 × 10~4 | Bouchard, 2011 |
BTNL9 | rs888949 | 5 | 180,425,011 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2.12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
RTN4IP1/QRSL1 | rs898896 | 6 | 107,169,855 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2.12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
HCG22 | rs2523849 | 6 | 31,133,030 | 0.17 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 7.53 × 10-5 | Bouchard, 2011 |
HCG22 | rs2523848 | 6 | 31,133,083 | 0.17 | 473 Caucasian | M & F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 7.53 × 10~5 | Bouchard, 2011 |
HCG22 | rs2428514 | 6 | 31,135,495 | 0.15 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 8.22 × 10-5 | Bouchard, 2011 |
HCG22 | rs2517518 | 6 | 31,136,324 | 0.17 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 7.53 × 10~5 | Bouchard, 2011 |
HCG22 | rs2523840 | 6 | 31,138,404 | 0.17 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 7.53 × 10-5 | Bouchard, 2011 |
HCG22 | rs2517506 | 6 | 31,139,659 | 0.17 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 7.53 × 10~5 | Bouchard, 2011 |
*PRDM1 (287 kb) | rs10499043 | 6 | 106,353,830 | 0.13 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | A (+) | 3.93 × 10-6 | Bouchard, 2011 |
*ENPP3 (17 kb) | rs10452621 | 6 | 132,127,094 | 0.12 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | A (+) | 1.23 × 10~4 | Bouchard, 2011 |
+SLC22A3 | rs2457571 | 6 | 160,754,818 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | Downregulated in high responders | 3.0 × 10−3 | Timmons, 2010 |
^TMEM181 | NA | 6 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #84.5 | Ghosh, 2013 |
^PARK2 | NA | 6 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #84.8 | Ghosh, 2013 |
^SNX14 | NA | 6 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #86.7 | Ghosh, 2013 |
^BTBD9 | NA | 6 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #86 | Ghosh, 2013 |
^KCNQ5 | NA | 6 | NA | NA | 473 Caucasian | 1.M&F 2. M | 1.17–65 2. young adults | 1.20 wks 2. 6–12 wks | 1. 3×/wk. 2. 3–4/wk | 1. 30–50 min 2. 45 min vs progressive | 1. 55–75% VO2max 2. 70% vs progressive | NA NA | 1:#85.9 2:NA | Ghosh, 2013 (1), Timmons, 2010 (2) |
PPARD | rs2076167 | 6 | 35,499,765 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | NA | Timmons, 2010 |
HDAC9 | rs3814991 | 7 | 18,601,428 | 0.11 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.46 × 10-4 | Bouchard, 2011 |
WBSCR17 (35 kb) | rs12538806 | 7 | 70,200,777 | 0.30 | 473 Caucasian | M & F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.47 × 10~4 | Bouchard, 2011 |
WBSCR17 (33 kb) | rs13235325 | 7 | 70,202,943 | 0.30 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.47 × 10-4 | Bouchard, 2011 |
++CPVL | rs4257918 | 7 | 29,020,374 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | Upregulated in high responders | 3.1 × 10−3 | Timmons, 2010 |
^ITGB8 | rs10265149 | 7 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 7.04 × 10−5 | Timmons, 2010 |
LHFPL3 | NA | 7 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 84.34 | Ghosh, 2013 |
PILRB | rs13228694 | 7 | 99,778,243 | NA | 41 Caucasian | Young adults | 17–65 | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
+DEPDC6 | rs7386139 | 8 | 121,096,600 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.85×10−2 | Timmons, 2010 |
#PINX1 | N/A | 8 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | NA | 88.2 | Ghosh, 2013 |
*GRIN3A (516 kb) | rs1535628 | 9 | 104,056,570 | 0.09 | 473 Caucasian | M & F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 6.81 × 10~6 | Bouchard, 2011 |
GRIN3A (540 kb) | rs959066 | 9 | 104,081,084 | 0.27 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.35 × 10-4 | Bouchard, 2011 |
*C9orf27 (33 kb) | rs12115454 | 9 | 117,759,871 | 0.11 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | G (+) | 7.74 × 10~5 | Bouchard, 2011 |
^TTLL11 | rs7022103 | 9 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.08 × 10−4 | Ghosh, 2013 |
KCNT1 | N/A | 9 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #86.5 | Ghosh, 2013 |
KLF4 | rs4631527 | 9 | 109,309,857 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
TET1 | rs12413410 | 10 | 70,055,236 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
PRKG1 | N/A | 10 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #87.3 | Ghosh, 2013 |
^+SVIL | rs6481619 | 10 | 30,022,960 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.0 × 10−3 | Timmons, 2010 |
+BTAF1 | rs2792022 | 10 | 93.730,409 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.2 × 10−2 | Timmons, 2010 |
CASC2 | rs1413184 | 10 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.65 × 10−4 | Ghosh, 2013 |
KIF5B | rs806819 | 10 | 32,403,990 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | NA | Timmons, 2010 |
+H19 | rs22551375 | 11 | 1,976,072 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | Upregulated in high responders | 4.0 × 10−4 | Timmons, 2010 |
ACTN3 | rs1815739 | 10 | 66,084,671 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | NA | Timmons, 2010 |
BTAF1 | rs2792022 | 10 | 93,730,409 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
*LOC100130460 | rs2198009 | 11 | 10,360,153 | 0.50 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | A (+) | 2.28 × 10-5 | Bouchard, 2011 |
*DBX1 (64 kb) | rs10500872 | 11 | 20,202,299 | 0.15 | 473 Caucasian | M & F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | A (+) | 6.49 × 10~6 | Bouchard, 2011 |
^*CD44 | rs353625 | 11 | 35,125,122 | 0.32 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | NA | 1:1.12 × 10– 4 2:1.64 × 10 −4 | Bouchard, 2011 (1) Ghosh, 2013 (2) |
CXCR5 (36 kb) | rs4938561 | 11 | 118,223,695 | 0.23 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 9.29 × 10~5 | Bouchard, 2011 |
* CXCR5 (24 kb/) BLR1 | rs7933007 | 11 | 118,235,879 | 0.23 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 7.35 × 10-5 | Bouchard, 2011 |
^CD6 | rs175098 | 11 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.11 × 10−4 | Ghosh, 2013 |
^SHANK2 | rs10751308 | 11 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | NA | 8.11 × 10 −5 | Ghosh, 2013 |
#GRIK4 | N/A | 11 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | NA | 88.32 | Ghosh, 2013 |
H19 | rs2251375 | 11 | 1,976,076 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
FAM19A2 | rs2168452 | 12 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.34 × 10−4 | Ghosh, 2013 |
^C12orf36 (14 kb) | rs12580476 | 12 | 13,435,330 | 0.14 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.08 × 10~4 2. 1.45 × 10−4 | Bouchard, 2011 (1) Ghosh, 2013 (2) |
^NALCN | N/A | 13 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | NA | #85 | Ghosh, 2013 |
+MIPEP | rs7324557 | 13 | 23,194,862 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 5.1 × 10−3 | Timmons, 2010 |
^EEF1DP3 | rs2773968 | 13 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 3.67 × 10−6 | Ghosh, 2013 |
^CLYBL | N/A | 13 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #85.4 | Ghosh, 2013 |
*TTC6 | rs12896790 | 14 | 37,343,673 | 0.09 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 3.59 × 10-5 | Bouchard, 2011 |
METTL3 | rs1263809 | 14 | 21,058,740 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
TTC6 | rs8018889 | 14 | 37,353,342 | 0.09 | 473 Caucasian | M & F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 5.25 × 10~5 | Bouchard, 2011 |
*DAAM1 | rs1956197 (14:g.59477414C > T) | 14 | 58,547,167 | 0.16 | 1. 473 Caucasian 2. 464 Caucasian | 1.M 2. F | 17–65 Post menopause | 20 wks 6 mths | 3×/wk. 120-170 min/wk | 30–50 min 120–170 min/wk | 55–75% VO 2 max +50%VO 2 max | AA (−) n = 84 | 1.43 × 10- 5 | Bouchard, 2011 |
*NDN (75 kb) Downstream of NDN | rs824205 | 15 | 21,559,164 | 0.15 | 1. 473 Caucasian 2. 464 Caucasian | 1.M 2.F | 17–65 Post menopause | 20 wks 9 mths | 3×/wk. 120-170 min/wk | 30–50 min 120-170 m in/wk | 55–75% VO 2 max 40–85%VO 2 max | GG (−) n = 521 | 3.45 × 10~ 5 0.05 | Bouchard, 2011 |
+DIS3L | rs1546570 | 15 | 64,382,829 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 2.3 × 10−2 | Timmons, 2010 |
UNKL | rs3751894 | 16 | 1,426,876 | NA | 473 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
IL32 | rs13335 | 16 | 3,052,198 | NA | 473 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
#RPTOR | N/A | 17 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | NA | #89 | Ghosh, 2013 |
#VPS53 | N/A | 17 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #84 | Ghosh, 2013 |
ACE | DI | 17 | 58,919,622 | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | NA | Timmons, 2010 |
SMTNL2 | rs7217556 | 17 | 4,425,585 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
ZSWIM7 | R21 | 17 | 15,825,286 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
ENOSF1 | rs3786355 | 18 | 671,962 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
EMR4 | rs7256163 | 19 | 6,909,134 | 0.31 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.13 × 10-4 | Bouchard, 2011 |
IER2 | rs892020 | 19 | 13,8185 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
DNAJB1 | rs4926222 | 19 | 14,488,050 | NA | 41 Caucasian | M | Young adults | 1.6 wks 2. 12 wks | 1. 4×/wk. 2. 3×/wk | 1. 45 min 2. Progressive | 1. 70% VO2max 2. Progressive | NA | NA | Timmons, 2010 |
g.63226200G > A | rs6090314 | 20 | 61,327,997 | 0.16 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | A (+) | 1:6.48 × 10~5 2:6.24 × 10−5 | Bouchard, 2011 (1) Ghosh, 2013 (2) |
^YTHDF1 | rs6122403 | 20 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 6.24 × 10−5 | Ghosh, 2013 |
^MACROD2 | N/A | 20 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO 2 max | NA | #86.6 | Ghosh, 2013 |
^HLS21 | N/A | 21 | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | #84.7 | Ghosh, 2013 |
*MN1 (14 kb) | rs738353 | 22 | 26,460,072 | 0.35 | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | A (+) | 1.23 × 10–4 | Bouchard, 2011 |
LOC731789 | rs11015207 | NA | NA | NA | 473 Caucasian | M&F | 17–65 | 20 wks | 3×/wk | 30–50 min | 55–75% VO2max | NA | 1.61 × 10−4 | Ghosh, 2013 |