Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE

Table 1 Single marker allelic association results of the 12 genetic variants included in the study

Chromosome	SNP	Gene	Position	Minor allele nucleotide	Minor allele frequency		P_BONF	OR	lower 95%CI	Upper 95%CI
					Centenarians	Controls
1	rs16835198	FNDC5	32,861,080	G	0.48	0.45	0.488	1.16	1.00	1.33
2	rs1050450	GPX1	49,357,401	T	0.08	0.08	1	0.95	0.73	1.25
4	rs6552828	ASCL1	1.85E + 08	G	0.40	0.41	1	0.95	0.82	1.10
6	rs4880	SOD2	1.6E + 08	G	0.13	0.14	1	0.94	0.77	1.16
8	rs7832552	TRHR	1.09E + 08	T	0.50	0.50	1	0.97	0.85	1.12
8	rs7460	PTK2	1.41E + 08	T	0.36	0.36	1	1.00	0.860	1.15
8	rs7843014	PTK2	1.41E + 08	A	0.25	0.27	1	0.88	0.75	1.04
9	rs1333049	CDKN2B-AS1	22,125,504	C	0.47	0.46	1	1.05	0.91	1.21
9	rs2802292	FOXO3A	108,587,315	G	0.29	0.28	1	1.05	0.90	1.23
11	rs1815739	ACTN3	66,560,624	C	0.46	0.47	1	0.96	0.84	1.11
19	rs429358	APOE	44,908,684	C	0.05	0.11	6.19 × 10⁻¹⁰	0.39	0.29	0.52
19	rs7412	APOE	44,908,882	T	0.07	0.04	0.002	1.80	1.32	2.46

Allele frequencies were compared using chi-square statistics; ORs and 95% confidence interval (95% CI) were calculated using Plink software
Abbreviations: 95%CI 95% confidence interval, OR odds ratio, P _BONF P-value after Bonferroni correction, SNP single nucleotide polymorphism

ISSN: 1471-2164