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Table 1 Single marker allelic association results of the 12 genetic variants included in the study

From: Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE

Chromosome SNP Gene Position Minor allele
nucleotide
Minor allele frequency PBONF OR lower 95%CI Upper 95%CI
      Centenarians Controls     
1 rs16835198 FNDC5 32,861,080 G 0.48 0.45 0.488 1.16 1.00 1.33
2 rs1050450 GPX1 49,357,401 T 0.08 0.08 1 0.95 0.73 1.25
4 rs6552828 ASCL1 1.85E + 08 G 0.40 0.41 1 0.95 0.82 1.10
6 rs4880 SOD2 1.6E + 08 G 0.13 0.14 1 0.94 0.77 1.16
8 rs7832552 TRHR 1.09E + 08 T 0.50 0.50 1 0.97 0.85 1.12
8 rs7460 PTK2 1.41E + 08 T 0.36 0.36 1 1.00 0.860 1.15
8 rs7843014 PTK2 1.41E + 08 A 0.25 0.27 1 0.88 0.75 1.04
9 rs1333049 CDKN2B-AS1 22,125,504 C 0.47 0.46 1 1.05 0.91 1.21
9 rs2802292 FOXO3A 108,587,315 G 0.29 0.28 1 1.05 0.90 1.23
11 rs1815739 ACTN3 66,560,624 C 0.46 0.47 1 0.96 0.84 1.11
19 rs429358 APOE 44,908,684 C 0.05 0.11 6.19 × 10−10 0.39 0.29 0.52
19 rs7412 APOE 44,908,882 T 0.07 0.04 0.002 1.80 1.32 2.46
  1. Allele frequencies were compared using chi-square statistics; ORs and 95% confidence interval (95% CI) were calculated using Plink software
  2. Abbreviations: 95%CI 95% confidence interval, OR odds ratio, P BONF P-value after Bonferroni correction, SNP single nucleotide polymorphism