Table 3 Allele frequency distribution of FNDC5 rs16835198 alleles according to APOE ε2/ε4 status in the study population
FNDC5 (rs16835198)allele | Absence of APOE ε4-allelea | Presence of APOE ε4-allelea | |||
Controls (2n = 1306) | Centenarians (2n = 1340) | Controls (2n = 336) | Centenarians (2n = 128) | ||
G | N | 570 | 648 | 165 | 62 |
% | 43.6% | 48.4% | 49.1% | 48.4% | |
P-value | 0.0167 | NS | |||
OR (95% CI) | 1.21 (1.04, 1.41) | – | |||
T | N | 736 | 692 | 171 | 66 |
% | 56.4% | 51.6% | 50.9% | 51.6% | |
P-value | 0.0167 | NS | |||
OR (95% CI) | 0.83 (0.71–0.96) | – | |||
FNDC5 (rs16835198)allele | Absence of APOE ε2-allelea | Presence of APOE ε2-allelea | |||
Controls (2n = 1508) | Centenarians (2n = 1258) | Controls (2n = 134) | Centenarians (2n = 210) | ||
G | n | 685 | 607 | 50 | 103 |
% | 45.4% | 48.3% | 37.3% | 49% | |
P-value | NS | 0.035 | |||
OR (95% CI) | – | 1.62 (1.04–2.52) | |||
T | n | 823 | 651 | 84 | 107 |
% | 54.6% | 51.7% | 62.7% | 51% | |
P-value | NS | 0.035 | |||
OR (95% CI) | – | 0.62 (0.40–0.96) | |||