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Table 3 Allele frequency distribution of FNDC5 rs16835198 alleles according to APOE ε2/ε4 status in the study population

From: Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE

FNDC5 (rs16835198)allele   Absence of APOE ε4-allelea Presence of APOE ε4-allelea
   Controls (2n = 1306) Centenarians (2n = 1340) Controls (2n = 336) Centenarians (2n = 128)
G N 570 648 165 62
% 43.6% 48.4% 49.1% 48.4%
P-value 0.0167 NS
OR (95% CI) 1.21 (1.04, 1.41)
T N 736 692 171 66
% 56.4% 51.6% 50.9% 51.6%
P-value 0.0167 NS
OR (95% CI) 0.83 (0.71–0.96)
FNDC5 (rs16835198)allele   Absence of APOE ε2-allelea Presence of APOE ε2-allelea
   Controls (2n = 1508) Centenarians (2n = 1258) Controls (2n = 134) Centenarians (2n = 210)
G n 685 607 50 103
% 45.4% 48.3% 37.3% 49%
P-value NS 0.035
OR (95% CI) 1.62 (1.04–2.52)
T n 823 651 84 107
% 54.6% 51.7% 62.7% 51%
P-value NS 0.035
OR (95% CI) 0.62 (0.40–0.96)
  1. Abbreviations: 95%CI 95% confidence interval, NS not significant, OR odds ratio
  2. aAll individuals underwent genotyping for rs429358 and rs7412. The 3 major isoforms of human APOE gene (E2, E3, and E4) coded by 3 alleles (ε2, ε3, and ε4) differ in amino acid sequence at 2 sites, residue 112 (rs429358) and residue 158 (rs7412)