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Table 4 Upstream regulators in the LD muscle of Laiwu pigs from 120 d to 240 d

From: Dynamic transcriptome and DNA methylome analyses on longissimus dorsi to identify genes underlying intramuscular fat content in pigs

Upstream regulator

Molecule type

Transcription

IPA prediction

Log2(FC)a

p-vale

Z-scoreb

p-value

CYR61

other

1.94

5.00E-05

1.82

1.17E-06

DRD2

G-protein coupled receptor

1.10

7.15E-03

0.51

3.96E-02

EGR1

transcription regulator

3.25

5.00E-05

3.39

1.23E-11

FGF1

growth factor

−0.85

1.08E-02

2.25

5.02E-05

GPER1

G-protein coupled receptor

1.54

3.00E-04

2.53

1.46E-04

ID2

transcription regulator

1.27

1.50E-04

−1.15

1.98E-04

KLF5

transcription regulator

0.66

1.00E-01

2.72

6.63E-05

KLF6

transcription regulator

0.25

3.36E-01

1.43

4.23E-04

LDLR

transporter

3.00

5.00E-05

1.00

1.66E-03

MIF

cytokine

0.93

2.00E-04

0.88

4.98E-02

MLXIPL

transcription regulator

−0.04

9.10E-01

1.97

3.64E-05

PLIN5

other

−0.16

5.72E-01

2.22

4.55E-02

POMC

other

0.58

9.77E-02

1.86

2.59E-03

SREBF1

transcription regulator

0.25

3.71E-01

1.45

5.53E-09

SREBF2

transcription regulator

1.13

3.99E-01

3.51

8.43E-05

TP53

transcription regulator

0.85

3.05E-03

2.67

4.83E-42

TWIST1

transcription regulator

0.64

3.13E-01

3.26

1.06E-11

  1. aFC: Fold-Change of FPKM in transcriptome data between two groups
  2. bZ-score: An IPA score method that reflects the activation state of predicted regulators