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Table 1 Functions of genes upregulated along different phases of wound response and healing in different tissues

From: Transcriptomic responses to wounding: meta-analysis of gene expression microarray data

Gene symbol Gene name Function of genes product
ANXA1 ↑ Annexin A1 membrane- phospholipid binding protein which has anti-inflammatory activity
ANXA2 ↑ Annexin A2 autocrine factor which enhances osteoclast formation and bone resorption
CCL2 ↑ C-c motif chemokine ligand 2 factor augmenting anti-tumor activity of monocytes
CD44 ↑ CD44 molecule (Indian blood group) receptor for hyaluronic acid interacting with osteopontin, collagens, and matrix metalloproteinases and involved in lymphocyte activation and homing, haematopoiesis, and metastasis
ICAM1 ↑ Intercellular Adhesion Molecule 1 cell surface glycoprotein expressed on endothelial and immune system cells
LGALS3 ↑ Galectin 3 plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation; exhibits antimicrobial activity
MMP12 ↑ Matrix metallopeptidase 12 (macrophage elastase) degrades elastin; involved in extracellular matrix breakdown in development, remodeling but also in aneurysm, metastasis
PDPN ↑ Podoplanin integral membrane glycoprotein proposed as a marker of lung injury
PTPRC ↑ * Protein Tyrosine Phosphatase, Receptor Type C essential regulator of T- and B-cell antigen receptor signaling; suppresses JAK kinases, thus functioning as a regulator of cytokine receptor signaling
SPP1 ↑ Secreted Phosphoprotein 1 involved in the attachment of osteoclasts to the mineralized bone matrix; a cytokine upregulating expression of interferon-gamma and interleukin-12
TIMP1 TIMP metallopeptidase inhibitor 1 inhibits most known matrix metalloproteinases; promotes cell proliferation in a wide range of cell types
AQP4 ↓* Aquaporin 4 water-selective channel in the plasma membrane; a predominant aquaporin found in brain
  1. The information on gene functions was derived from the data collected in the GeneCards database (, which includes (Entrez Gene summary and UniProtKB/Swiss-Prot:Function)
  2. The downregulated gene is marked with a downwards arrow↓, the upregulated genes are indicated with upwards arrows↑. 
  3. The genes which have not been reported so far among the main players in wound response are distinguished with asterisks